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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tgfbr2tm1Roes
targeted mutation 1, Jurgen Roes
MGI:3045693
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cd19tm1(cre)Cgn/Cd19+
Tgfbr2tm1Roes/Tgfbr2tm1Roes
involves: 129P2/OlaHsd * BALB/c MGI:3051965
cn2
Mob1atm1.1Asuz/Mob1atm1.1Asuz
Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Tgfbr2tm1Roes/Tgfbr2tm1Roes
involves: 129P2/OlaHsd * C57BL/6 * DBA MGI:5897816
cn3
Dcttm1(cre)Bee/Dcttm1(cre)Bee
Tgfbr2tm1Roes/Tgfbr2tm1Roes
Tg(Dct-lacZ)A12Jkn/0
involves: 129/Sv * C57BL/6 * C57BL/6J * CBA MGI:6241339


Genotype
MGI:3051965
cn1
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic
Background
involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Tgfbr2tm1Roes mutation (2 available); any Tgfbr2 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• IgA expressing plasma cells are virtually absent from the spleen and bone marrow of mutants
• a 3 fold increase in leukocyte numbers is seen
• increased proliferation of mature splenic B cells is seen, however a decrease in B-1 cell proliferation and increase in B-1 cell survival time are also seen
• more activated B cells are found in mutants
• sera from 9 week or 8 month old mutants shows increased binding to double stranded DNA indicating impaired control of B cell activation
• serum IgA levels are reduced by about 10 fold and are not increased in response to antigens
• serum levels of all IgG subclasses are increased with IgG1 showing the largest increase (16 fold)
• IgG3 antigen-induced expression is greatly increased
• serum IgM levels and IgM expression by peripheral B cells are increased

immune system
• IgA expressing plasma cells are virtually absent from the spleen and bone marrow of mutants
• a 3 fold increase in leukocyte numbers is seen
• increased proliferation of mature splenic B cells is seen, however a decrease in B-1 cell proliferation and increase in B-1 cell survival time are also seen
• more activated B cells are found in mutants
• sera from 9 week or 8 month old mutants shows increased binding to double stranded DNA indicating impaired control of B cell activation
• serum IgA levels are reduced by about 10 fold and are not increased in response to antigens
• serum levels of all IgG subclasses are increased with IgG1 showing the largest increase (16 fold)
• IgG3 antigen-induced expression is greatly increased
• serum IgM levels and IgM expression by peripheral B cells are increased
• Peyer's patches are larger and more distinct




Genotype
MGI:5897816
cn2
Allelic
Composition
Mob1atm1.1Asuz/Mob1atm1.1Asuz
Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mob1atm1.1Asuz mutation (0 available); any Mob1a mutation (18 available)
Mob1bGt(CC0690)Wtsi mutation (0 available); any Mob1b mutation (21 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Tgfbr2tm1Roes mutation (2 available); any Tgfbr2 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• increased immature cholangiocyte-like and oval cells but not as much as in Mob1atm1.1Asuz/Mob1atm1.1Asuz Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi Tg(Alb-cre)21Mgn mice
• not as much as in Mob1atm1.1Asuz/Mob1atm1.1Asuz Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi Tg(Alb-cre)21Mgn mice
• not as much as in Mob1atm1.1Asuz/Mob1atm1.1Asuz Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi Tg(Alb-cre)21Mgn mice

endocrine/exocrine glands
• increased immature cholangiocyte-like and oval cells but not as much as in Mob1atm1.1Asuz/Mob1atm1.1Asuz Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi Tg(Alb-cre)21Mgn mice

growth/size/body
• not as much as in Mob1atm1.1Asuz/Mob1atm1.1Asuz Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi Tg(Alb-cre)21Mgn mice




Genotype
MGI:6241339
cn3
Allelic
Composition
Dcttm1(cre)Bee/Dcttm1(cre)Bee
Tgfbr2tm1Roes/Tgfbr2tm1Roes
Tg(Dct-lacZ)A12Jkn/0
Genetic
Background
involves: 129/Sv * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcttm1(cre)Bee mutation (1 available); any Dct mutation (35 available)
Tg(Dct-lacZ)A12Jkn mutation (5 available)
Tgfbr2tm1Roes mutation (2 available); any Tgfbr2 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• 73.3% of mice exhibit mild but accelerated hair graying within 10 months after birth relative to control mice; the frequency of gray hairs is variable depending on the individual mouse
• hair graying is likely caused by incomplete maintenance of melanocyte stem cells
• late anagen follicles exhibit LacZ+ dendritic and slightly pigmented melanocytes with large cell bodies in the bulge-subbulge area; in contrast, LacZ+ melanoblasts in the bulge area of control follicles are immature and small with minimal dendrites, typical features of melanocyte stem cells
• at 6 months of age, the frequency of hair follicles with large and dendritic melanocytes or pigmented melanocytes in the bulge area of anagen IV-VI follicles is significantly higher than that in control follicles
• some follicles show complete loss of Dct-lacZ+ cells in the bulge area, suggesting that melanocyte stem cells have prematurely differentiated and are eventually depleted from the stem cell niche
• melanocyte stem cells are lost in the bulge area of almost all follicles that produce white hair
• in contrast, the distribution of epidermal and dermal melanocytes in the pigmented junctional epithelium is normal
• mice exhibit deposition of melanin pigment in the bulge area of midanagen hair follicles
• melanin incontinence in the dermal papillae of hair follicles occurs more frequently than in control follicles
• midanagen hair follicles begin to show ectopically pigmented melanocytes with dendritic morphologies starting from the second hair cycle
• ectopically differentiated melanocytes are preferentially seen in follicles that show pigmentation defects in the hair matrix

integument
• 73.3% of mice exhibit mild but accelerated hair graying within 10 months after birth relative to control mice; the frequency of gray hairs is variable depending on the individual mouse
• hair graying is likely caused by incomplete maintenance of melanocyte stem cells
• late anagen follicles exhibit LacZ+ dendritic and slightly pigmented melanocytes with large cell bodies in the bulge-subbulge area; in contrast, LacZ+ melanoblasts in the bulge area of control follicles are immature and small with minimal dendrites, typical features of melanocyte stem cells
• at 6 months of age, the frequency of hair follicles with large and dendritic melanocytes or pigmented melanocytes in the bulge area of anagen IV-VI follicles is significantly higher than that in control follicles
• some follicles show complete loss of Dct-lacZ+ cells in the bulge area, suggesting that melanocyte stem cells have prematurely differentiated and are eventually depleted from the stem cell niche
• melanocyte stem cells are lost in the bulge area of almost all follicles that produce white hair
• in contrast, the distribution of epidermal and dermal melanocytes in the pigmented junctional epithelium is normal
• mice exhibit deposition of melanin pigment in the bulge area of midanagen hair follicles
• melanin incontinence in the dermal papillae of hair follicles occurs more frequently than in control follicles





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory