hematopoietic system
• IgA expressing plasma cells are virtually absent from the spleen and bone marrow of mutants
|
• a 3 fold increase in leukocyte numbers is seen
|
• increased proliferation of mature splenic B cells is seen, however a decrease in B-1 cell proliferation and increase in B-1 cell survival time are also seen
|
• more activated B cells are found in mutants
• sera from 9 week or 8 month old mutants shows increased binding to double stranded DNA indicating impaired control of B cell activation
|
• serum IgA levels are reduced by about 10 fold and are not increased in response to antigens
|
• serum levels of all IgG subclasses are increased with IgG1 showing the largest increase (16 fold)
• IgG3 antigen-induced expression is greatly increased
|
• serum IgM levels and IgM expression by peripheral B cells are increased
|
immune system
• IgA expressing plasma cells are virtually absent from the spleen and bone marrow of mutants
|
• a 3 fold increase in leukocyte numbers is seen
|
• increased proliferation of mature splenic B cells is seen, however a decrease in B-1 cell proliferation and increase in B-1 cell survival time are also seen
|
• more activated B cells are found in mutants
• sera from 9 week or 8 month old mutants shows increased binding to double stranded DNA indicating impaired control of B cell activation
|
• serum IgA levels are reduced by about 10 fold and are not increased in response to antigens
|
• serum levels of all IgG subclasses are increased with IgG1 showing the largest increase (16 fold)
• IgG3 antigen-induced expression is greatly increased
|
• serum IgM levels and IgM expression by peripheral B cells are increased
|
• Peyer's patches are larger and more distinct
|