Analysis Tools
mortality/aging
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• two thirds of those that survive past E12 die at birth
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• half of the homozygous mutant embryos die around E11 - E12
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cardiovascular system
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• at E10.5 inversion of cardiac looping is seen in 19% of mutant embryos
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dextrocardia
(
J:89880
)
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• at E18, 6 out of 10 mutant embryos had meso- or dextrocardia
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mesocardia
(
J:89880
)
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• at E18, 6 out of 10 mutant embryos had meso- or dextrocardia
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embryo
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• from E7.25 to E8.0 growth of nodal cilia is significantly delayed resulting in significantly shorter cilia in homozygous embryos
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• at E10.5 inversion of embryo turning is seen in 19% of mutant embryos
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• markers that are normally expressed only on the left side are expressed on both sides
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growth/size/body
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• mutants are about two thirds the size of wild-type littermates at birth
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• growth retardation increases as the mutant mice age with adults body weight being about half that of control littermates
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• 6% of those mutants that survive past birth have situs inversus
• at E18, 6% of mutant embryos had situs inversus and 29% had incomplete inversion defects
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cellular
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• from E7.25 to E8.0 growth of nodal cilia is significantly delayed resulting in significantly shorter cilia in homozygous embryos
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