normal phenotype
• homozygous mutants have no obvious phenotype
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Allele Symbol Allele Name Allele ID |
Rfx3tm2Wrth targeted mutation 2, W Reith MGI:3045793 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• homozygous mutants have no obvious phenotype
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• normal hearing thresholds at 3 months of age
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time
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• widespread loss of outer hair cells by P15
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• by P90
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• progressive degeneration associated with sporadic fusion of stereocilia on some of the remaining bundles by P90
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• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15
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• rapid progressive hearing loss beginning at P22 with no measurable hearing by 3 months of age
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• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time
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• widespread loss of outer hair cells by P15
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• by P90
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• progressive degeneration associated with sporadic fusion of stereocilia on some of the remaining bundles by P90
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• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15
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• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time
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• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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