Phenotypes associated with this allele

• Allele Symbol: Sfrp1^tm1Bsk
• Allele Name: targeted mutation 1, Barry S Komm
• Allele ID: MGI:3045799
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sfrp1^tm1Bsk/Sfrp1^tm1Bsk	involves: 129S5/SvEvBrd * C57BL/6	MGI:3045879

Genotype
MGI:3045879

hm1

• Allelic Composition: Sfrp1^tm1Bsk/Sfrp1^tm1Bsk
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:89547 )

• percent body fat is decreased by 22% in male mutants compared to wild-type mice

cardiovascular system

increased heart weight ( J:89547 )

• homozygous females have increased heart weights compared to wild-type mice

hematopoietic system

decreased leukocyte cell number ( J:89547 )

• 40 week old male homozygotes have decreased total white blood cell counts

decreased neutrophil cell number ( J:89547 )

• 40 week old male homozygotes have decreased segmented neutrophil values

decreased lymphocyte cell number ( J:89547 )

• 40 week old male homozygotes have decreased lymphocyte values

homeostasis/metabolism

increased circulating phosphate level ( J:89547 )

• serum phosphorus is elevated by 29% in 18 - 20 week old male mutants but not in females or in either sex at 39 - 40 weeks of age

immune system

decreased leukocyte cell number ( J:89547 )

• 40 week old male homozygotes have decreased total white blood cell counts

decreased neutrophil cell number ( J:89547 )

• 40 week old male homozygotes have decreased segmented neutrophil values

decreased lymphocyte cell number ( J:89547 )

• 40 week old male homozygotes have decreased lymphocyte values

skeleton

abnormal trabecular bone morphology ( J:89547 )

• trabecular bone area is increased in 35 - 40 week old mutants as a result of prolonged bone accrual and decreased apoptosis of osteoblasts and osteocytes

• no changes in bone resorption markers are seen

nervous system

decreased brain weight ( J:89547 )

• mutants have decreased brain weights

growth/size/body

increased heart weight ( J:89547 )

• homozygous females have increased heart weights compared to wild-type mice