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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kittm1Ber
targeted mutation 1, Alan Bernstein
MGI:3045801
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kittm1Ber/Kittm1Ber involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3045954
ht2
 		Kittm1Ber/Kit+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3045958


Genotype
MGI:3045954
hm1
Allelic
Composition		 Kittm1Ber/Kittm1Ber
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kittm1Ber mutation (0 available); any Kit mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
absent coat pigmentation ( J:89602 )
• in regions where the coat was white, melanin pigment was absent from the hair shafts and melanocytes were absent from the hair bulbs
variable depigmentation ( J:89602 )
• observed in 10% to 15% of mice
• >90% of the body surface area white except around the ear

digestive/alimentary system
digestive/alimentary phenotype ( J:89602 )
N
• neither stomach or intestinal distension were observed as was in Kittm3Ber/tm3Ber mice

hematopoietic system
decreased mast cell number ( J:89602 )
• reduced number of mast cells in the peritoneal cavity, and the stomach
• normal number of mast cell precursor cells and it was possible to derive mast cells from the bone marrow

immune system
immune system phenotype ( J:89602 )
N
• splenomegaly was not observed, as it was in Kittm3Ber/tm3Ber mice
decreased mast cell number ( J:89602 )
• reduced number of mast cells in the peritoneal cavity, and the stomach
• normal number of mast cell precursor cells and it was possible to derive mast cells from the bone marrow

reproductive system
reproductive system phenotype ( J:89602 )
N
• mice were fully fertile

integument
absent coat pigmentation ( J:89602 )
• in regions where the coat was white, melanin pigment was absent from the hair shafts and melanocytes were absent from the hair bulbs
variable depigmentation ( J:89602 )
• observed in 10% to 15% of mice
• >90% of the body surface area white except around the ear




Genotype
MGI:3045958
ht2
Allelic
Composition		 Kittm1Ber/Kit+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kittm1Ber mutation (0 available); any Kit mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
absent coat pigmentation ( J:89602 )
• in regions where the coat was white, melanin pigment was absent from the hair shafts and melanocytes were absent from the hair bulbs
variable depigmentation ( J:89602 )
• observed in 2% to 5% of mice
• >90% of the body surface area white except around the ear

reproductive system
reproductive system phenotype ( J:89602 )
N
• mice were fully fertile

integument
absent coat pigmentation ( J:89602 )
• in regions where the coat was white, melanin pigment was absent from the hair shafts and melanocytes were absent from the hair bulbs
variable depigmentation ( J:89602 )
• observed in 2% to 5% of mice
• >90% of the body surface area white except around the ear




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory