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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ddx25tm1Mld
targeted mutation 1, Maria L Dufau
MGI:3045804
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ddx25tm1Mld/Ddx25tm1Mld involves: 129S4/SvJae MGI:3045884
ht2
 		Ddx25tm1Mld/Ddx25+ involves: 129S4/SvJae MGI:3045885


Genotype
MGI:3045884
hm1
Allelic
Composition		 Ddx25tm1Mld/Ddx25tm1Mld
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx25tm1Mld mutation (1 available); any Ddx25 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased male germ cell apoptosis ( J:89546 )
• germ cell apoptosis is increased to greater than 30% per tubule in homozygous males
abnormal Leydig cell morphology ( J:89546 )
• Leydig cells contain fewer lipid droplets and swollen mitochondria withou normal central cristae, however basal circulating testosterone levels are normal
decreased testis weight ( J:89546 )
• testes weight is reduced by 25% in mutants
abnormal spermatogenesis ( J:89546 )
• chromatid bodies are unusually condensed, much smaller, and lack the typical amorphous 'nuage' texture throughout spermatogenesis
arrest of spermatogenesis ( J:89546 )
• spermatogenesis arrests after step 8 with round spermatids but no elongating cells seen
• only degenerating spermatids are seen in the epididymis
male infertility ( J:89546 )
• homozygous mutant males are sterile, but mutant females are fertile

endocrine/exocrine glands
abnormal Leydig cell morphology ( J:89546 )
• Leydig cells contain fewer lipid droplets and swollen mitochondria withou normal central cristae, however basal circulating testosterone levels are normal
decreased testis weight ( J:89546 )
• testes weight is reduced by 25% in mutants

cellular
increased male germ cell apoptosis ( J:89546 )
• germ cell apoptosis is increased to greater than 30% per tubule in homozygous males




Genotype
MGI:3045885
ht2
Allelic
Composition		 Ddx25tm1Mld/Ddx25+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx25tm1Mld mutation (1 available); any Ddx25 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal apoptosis ( J:89546 )
• germ cell apoptosis is increased in heterozygous males




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory