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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		MybPlt4
Plt4
MGI:3045843
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Mpltm1Wsa/Mpltm1Wsa
MybPlt4/MybPlt4 		involves: 129S1/Sv * C57BL/6 MGI:3045897
cx2
 		Mpltm1Wsa/Mpltm1Wsa
MybPlt4/Myb+ 		involves: 129S1/Sv * C57BL/6 MGI:3045898


Genotype
MGI:3045897
cx1
Allelic
Composition		 Mpltm1Wsa/Mpltm1Wsa
MybPlt4/MybPlt4
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpltm1Wsa mutation (1 available); any Mpl mutation (48 available)
MybPlt4 mutation (0 available); any Myb mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal megakaryocyte differentiation ( J:89601 )
• increased numbers of progenitor cells and megakaryocytes in both bone marrow and in spleen
abnormal definitive hematopoiesis ( J:89601 )
• numbers of most progenitor cell lines are elevated
abnormal erythropoiesis ( J:89601 )
• defective production of erythroid lineages
• large numbers of erythroid colony forming units but defective maturation
thrombocytosis ( J:89601 )
• supraphysiological levels
decreased leukocyte cell number ( J:89601 )
• leukopenic
• significantly reduced numbers of B cells in bone marrow and spleen
increased spleen red pulp amount ( J:89601 )
• expanded red pulp with abnormal architecture
decreased spleen B cell follicle size ( J:89601 )
• abnormally small lymphoid follicles

immune system
decreased leukocyte cell number ( J:89601 )
• leukopenic
• significantly reduced numbers of B cells in bone marrow and spleen
increased spleen red pulp amount ( J:89601 )
• expanded red pulp with abnormal architecture
decreased spleen B cell follicle size ( J:89601 )
• abnormally small lymphoid follicles

cellular
abnormal megakaryocyte differentiation ( J:89601 )
• increased numbers of progenitor cells and megakaryocytes in both bone marrow and in spleen




Genotype
MGI:3045898
cx2
Allelic
Composition		 Mpltm1Wsa/Mpltm1Wsa
MybPlt4/Myb+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpltm1Wsa mutation (1 available); any Mpl mutation (48 available)
MybPlt4 mutation (0 available); any Myb mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal megakaryocyte differentiation ( J:89601 )
• increased numbers of progenitor cells and megakaryocytes in both bone marrow and in spleen
abnormal definitive hematopoiesis ( J:89601 )
• numbers of most progenitor cell lines are unchanged
thrombocytosis ( J:89601 )
• amelioration of thrombocytopenia compared to Mpltm1Wsa but not to wild-type

cellular
abnormal megakaryocyte differentiation ( J:89601 )
• increased numbers of progenitor cells and megakaryocytes in both bone marrow and in spleen

immune system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory