Phenotypes associated with this allele

• Allele Symbol: Rasgrf1^tm1Sva
• Allele Name: targeted mutation 1, Alcino J Silva
• Allele ID: MGI:3045890
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rasgrf1^tm1Sva/Rasgrf1^tm1Sva	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3046102
cx2	Rasgrf1^tm1Sva/Rasgrf1^tm1Sva Rasgrf2^tm1Feig/Rasgrf2^tm1Feig	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3046171

Genotype
MGI:3046102

hm1

• Allelic Composition: Rasgrf1^tm1Sva/Rasgrf1^tm1Sva
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal discrimination learning ( J:91065 )

• mutants fail to discriminate between two similar environments differentiated by the inclusion or absence of a shock

impaired social transmission of food preference ( J:91065 )

• 21 hours after interaction with the demonstrator mouse mutants fail to show a preference for the cued food

abnormal spatial learning ( J:91065 )

• in a Morris water maze mutants take longer to find the platform and when the platform is removed cross its former location less frequently

growth/size/body

decreased body weight ( J:91065 )

• by 8 weeks of age mutants males and females weigh 23% and 10% less, respectively, than their sex-matched wild-type littermates

Genotype
MGI:3046171

cx2

• Allelic Composition: Rasgrf1^tm1Sva/Rasgrf1^tm1Sva; Rasgrf2^tm1Feig/Rasgrf2^tm1Feig
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

nervous system

increased susceptibility to ischemic brain injury ( J:90111 )

• stroke induced by occlusion of the right middle cerebral artery resulted in about 2 fold larger lesions in double homozygous mice

• no or only slight increases in the size of lesions is seen in either single homozygote

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:90111 )

• stroke induced by occlusion of the right middle cerebral artery resulted in about 2 fold larger lesions in double homozygous mice

• no or only slight increases in the size of lesions is seen in either single homozygote