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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Card11tm1Pngr
targeted mutation 1, Josef M Penninger
MGI:3045950
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Card11tm1Pngr/Card11tm1Pngr involves: 129P2/OlaHsd MGI:3046090
hm2
 		Card11tm1Pngr/Card11tm1Pngr involves: 129P2/OlaHsd * C57BL/6 MGI:3716872


Genotype
MGI:3046090
hm1
Allelic
Composition		 Card11tm1Pngr/Card11tm1Pngr
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11tm1Pngr mutation (0 available); any Card11 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:84036 )
• B cell numbers and differentiation normal in bone marrow
• defect in terminal differentiation of mature B cells
• enhanced cell death in B cells but not T cells
absent B-1a cells ( J:84036 )
• peritoneal CD5+ B1 cells are absent
decreased NK cell number ( J:84036 )
• reduced numbers of natural killer cells in spleen
abnormal B cell physiology ( J:84036 )
• response to T-cell independent antigens abolished
decreased B cell proliferation ( J:84036 )
• B cell proliferation in the spleen markedly impaired
decreased IgE level ( J:84036 )
• undetectable
decreased IgG level ( J:84036 )
• reduced levels of IgG1, IgG2a, IgGb, IgG3
abnormal T cell activation ( J:84036 )
• impaired response to T-cell dependent antigen
• antigen mediated T-cell activation decreased dramatically

immune system
abnormal B cell differentiation ( J:84036 )
• B cell numbers and differentiation normal in bone marrow
• defect in terminal differentiation of mature B cells
• enhanced cell death in B cells but not T cells
absent B-1a cells ( J:84036 )
• peritoneal CD5+ B1 cells are absent
decreased NK cell number ( J:84036 )
• reduced numbers of natural killer cells in spleen
abnormal B cell physiology ( J:84036 )
• response to T-cell independent antigens abolished
decreased B cell proliferation ( J:84036 )
• B cell proliferation in the spleen markedly impaired
decreased IgE level ( J:84036 )
• undetectable
decreased IgG level ( J:84036 )
• reduced levels of IgG1, IgG2a, IgGb, IgG3
abnormal T cell activation ( J:84036 )
• impaired response to T-cell dependent antigen
• antigen mediated T-cell activation decreased dramatically
abnormal interleukin-2 secretion ( J:84036 )
• defective Il-2 production

cellular
decreased B cell proliferation ( J:84036 )
• B cell proliferation in the spleen markedly impaired




Genotype
MGI:3716872
hm2
Allelic
Composition		 Card11tm1Pngr/Card11tm1Pngr
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11tm1Pngr mutation (0 available); any Card11 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:122394 )
N
• stimulation through FcR results in normal production of TNF and Il-2
• stimulation by Toll-like receptor ligands results in normal cytokine production




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory