Phenotypes associated with this allele

• Allele Symbol: Card11^unm
• Allele Name: unmodulated
• Allele ID: MGI:3045963
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Card11^unm/Card11^unm	C57BL/6JSfdAnu-Card11^unm/Anu	MGI:3046105

Genotype
MGI:3046105

hm1

• Allelic Composition: Card11^unm/Card11^unm
• Genetic Background: C57BL/6JSfdAnu-Card11^unm/Anu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

spleen hyperplasia ( J:84042 )

• increased cellularity in spleen

• frequencies of T and B cells in spleen normal

abnormal B cell differentiation ( J:84042 )

• shift to higher levels of surface IgM and CD21

• antigen responses decreased or absent

• Th1 type antibody response more affected than Th2 type response

• lower responses to B cell activating stimuli

• B cell responses selectively impaired

decreased B-1 B cell number ( J:84042 )

• peritoneal B1 cells are nearly absent but B2 cells unaffected

decreased immunoglobulin level ( J:84042 )

decreased IgG3 level ( J:84042 )

• 90% reduction in IgG3 levels in serum

• overall IgG levels about normal

decreased IgM level ( J:84042 )

• 50% decrease in IgM levels in serum

increased immunoglobulin level ( J:84042 )

increased IgE level ( J:84042 )

• high serum levels develop with age

abnormal T cell activation ( J:84042 )

• defective CD28 costimulation of T cells but T cell activation otherwise normal

immune system

spleen hyperplasia ( J:84042 )

• increased cellularity in spleen

• frequencies of T and B cells in spleen normal

abnormal B cell differentiation ( J:84042 )

• shift to higher levels of surface IgM and CD21

• antigen responses decreased or absent

• Th1 type antibody response more affected than Th2 type response

• lower responses to B cell activating stimuli

• B cell responses selectively impaired

decreased B-1 B cell number ( J:84042 )

• peritoneal B1 cells are nearly absent but B2 cells unaffected

lymph node hyperplasia ( J:84042 )

• increased cellularity in lymph nodes

• frequencies of T and B cells in lymph nodes normal

abnormal immune system physiology ( J:84042 )

decreased immunoglobulin level ( J:84042 )

decreased IgG3 level ( J:84042 )

• 90% reduction in IgG3 levels in serum

• overall IgG levels about normal

decreased IgM level ( J:84042 )

• 50% decrease in IgM levels in serum

increased immunoglobulin level ( J:84042 )

increased IgE level ( J:84042 )

• high serum levels develop with age

abnormal T cell activation ( J:84042 )

• defective CD28 costimulation of T cells but T cell activation otherwise normal

increased inflammatory response ( J:84042 )

• teary eyes

dermatitis ( J:84042 )

• dermatitis develops on ears and neck

• hyperkeratosis of inflamed regions of skin

erythroderma ( J:84042 )

• erythematous ears at 10-20 weeks

• become intensely itchy

integument

dermatitis ( J:84042 )

• dermatitis develops on ears and neck

• hyperkeratosis of inflamed regions of skin

erythroderma ( J:84042 )

• erythematous ears at 10-20 weeks

• become intensely itchy

growth/size/body

spleen hyperplasia ( J:84042 )

• increased cellularity in spleen

• frequencies of T and B cells in spleen normal