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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Srcr
spontaneous regression or complete resistance
MGI:3045964
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Srcr/Srcr+ B6.C-Srcr/Cui MGI:3045967
ht2
Srcr/Srcr+ BALB/c-Srcr/Cui MGI:3045966
ht3
Srcr/Srcr+ CAST.C-Srcr/Cui MGI:6192554
cx4
Foxn1nu/Foxn1nu
Srcr/Srcr+
involves: BALB/c * C57BL/6 MGI:3045968


Genotype
MGI:3045967
ht1
Allelic
Composition
Srcr/Srcr+
Genetic
Background
B6.C-Srcr/Cui
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• injection of tumor forming cells does not result in tumor formation or results in tumor formation followed by spontaneous regression




Genotype
MGI:3045966
ht2
Allelic
Composition
Srcr/Srcr+
Genetic
Background
BALB/c-Srcr/Cui
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• injection of tumor forming cells at 6 weeks of age does not result in tumor formation
• when the first injection of tumor forming cells is given at 12 or 22 weeks of age tumors form in 50% or most mutants, respectively, but then spontaneously regress

immune system
• mutants are able to destroy more of the tumor forming cells such that by 7 days after injection none of the injected cells are found in contrast to wild-type mice where the injected cells are the predominant cell in the peritoneal cavity
• leukocytes, mainly from the innate immune system, form rosettes and large cellular aggregates around the injected tumor forming cells these structures are not seen in wild-type mice




Genotype
MGI:6192554
ht3
Allelic
Composition
Srcr/Srcr+
Genetic
Background
CAST.C-Srcr/Cui
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• injection of tumor forming cells does not result in tumor formation or results in tumor formation followed by spontaneous regression




Genotype
MGI:3045968
cx4
Allelic
Composition
Foxn1nu/Foxn1nu
Srcr/Srcr+
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (106 available)
Srcr mutation (0 available); any Srcr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• injection of tumor forming cells does not result in tumor formation or results in tumor formation followed by spontaneous regression





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory