All Phenotypes Hoxb4<tm1.1Karl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxb4^tm1.1Karl
targeted mutation 1.1, Stefan Karlsson
MGI:3045971

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxb4^tm1.1Karl/Hoxb4^tm1.1Karl	involves: 129 * C57BL/6J	MGI:3046064

Allelic Composition	Hoxb4^tm1.1Karl/Hoxb4^tm1.1Karl
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb4^tm1.1Karl mutation (1 available); any Hoxb4 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:90976 )

• the proliferative response of primitive hematopoietic progenitor cells is decreased

decreased bone marrow cell number ( J:90976 )

• a significant decrease in bone marrow cellularity is seen

decreased erythrocyte cell number ( J:90976 )

• a small but significant decrease in red blood cell count is seen

decreased hemoglobin content ( J:90976 )

• a small but significant decrease in hemoglobin content is seen

spleen hypoplasia ( J:90976 )

• a significant decrease in the cellularity of the spleen is seen

immune system

spleen hypoplasia ( J:90976 )

• a significant decrease in the cellularity of the spleen is seen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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