Analysis Tools
mortality/aging
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• male homozygotes and to a lesser extent female homozygotes die prematurely
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endocrine/exocrine glands
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• extensive suppurative glandular and periglandular inflammatory cell infiltrate of the prostate is seen
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growth/size/body
hematopoietic system
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• bone marrow hyperplasia is seen in some mutants
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• lymphoid atrophy is seen in some mutants
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homeostasis/metabolism
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• moribund mutants have elevated blood urea nitrogen levels
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• moribund mutants have proteinuria
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immune system
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• extensive suppurative glandular and periglandular inflammatory cell infiltrate of the prostate is seen
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• lymphoid atrophy is seen in some mutants
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• urinary tract infections with pyelonephritis and tuberulointerstitial nephritis are seen
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• extensive suppurative glandular and periglandular inflammatory cell infiltrate of the seminal vesicles is seen
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renal/urinary system
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• moribund mutants have proteinuria
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• urinary tract infections with pyelonephritis and tuberulointerstitial nephritis are seen
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• 6 week old homozygous mice have weak voiding contractions which progresses to no voiding contractions in 8 week old mutants
• nerve fiber density is decreased in homozygous mutants
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• the renal pelvis is dilated as the result of urinary tract obstruction
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• in males hyperplasia of the prostatic urethral epithelium and surrounding smooth muscle is seen
• proteinaceous plugs are found in the proximal urethra of male mutants
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• proteinaceous plugs are found in the proximal urethra of male mutants
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• urinary bladder hypertrophy by 6 weeks of age in both male and female mice
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• hyperplasia and hypertrophy of the urinary bladder detrusor smooth muscle
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• proteinaceous plugs are found in the bladder neck of male mutants
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• hyperplasia and hypertrophy of the urinary bladder epithelium
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• significantly increased urinary bladder weight by 6 weeks of age, with a 2- to 3-fold increase in urinary bladder to body weight ratio
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• the urinary bladder is hyperdistended
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• proteinaceous plugs are found in the bladder neck of male mutants
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• homozygous mice have overflow incontinence with constant urine dribbling
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reproductive system
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• extensive suppurative glandular and periglandular inflammatory cell infiltrate of the prostate is seen
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• extensive suppurative glandular and periglandular inflammatory cell infiltrate of the seminal vesicles is seen
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nervous system
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• 6 week old homozygous mice have weak voiding contractions which progresses to no voiding contractions in 8 week old mutants
• nerve fiber density is decreased in homozygous mutants
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muscle
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• hyperplasia and hypertrophy of the urinary bladder detrusor smooth muscle
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