Phenotypes associated with this allele

• Allele Symbol: Rho^{tm2(RHO/GFP)Jhw}
• Allele Name: targeted mutation 2, John H Wilson
• Allele ID: MGI:3046186
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rho^tm2(RHO/GFP)Jhw/Rho^tm2(RHO/GFP)Jhw	either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyr^c * FVB)	MGI:3046194
hm2	Rho^tm2(RHO/GFP)Jhw/Rho^tm2(RHO/GFP)Jhw	involves: 129S7/SvEvBrd	MGI:3836175
ht3	Rho^tm2(RHO/GFP)Jhw/Rho^+	either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyr^c * FVB)	MGI:3046195
cx4	Pde6b^rd1/Pde6b^rd1 Rho^tm2(RHO/GFP)Jhw/Rho^+	either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyr^c * FVB)	MGI:3046197

Genotype
MGI:3046194

hm1

• Allelic Composition: Rho^{tm2(RHO/GFP)Jhw}/Rho^{tm2(RHO/GFP)Jhw}
• Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyr^c * FVB)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

retina degeneration ( J:91038 )

• retinas begin to degenerate within a 3-5 months after birth

• retinal degeneration is not as severe as in Rho^tm3Jhw homozygote

Genotype
MGI:3836175

hm2

• Allelic Composition: Rho^{tm2(RHO/GFP)Jhw}/Rho^{tm2(RHO/GFP)Jhw}
• Genetic Background: involves: 129S7/SvEvBrd

vision/eye

abnormal retina layer morphology ( J:128212 )

• thin

abnormal retina photoreceptor morphology ( J:128212 )

• the outer and inner segment boundaries are difficult to distinguish at 3, 6, and 8 weeks

abnormal photoreceptor outer segment morphology ( J:128212 )

• at 2 weeks, nascent rod outer segments exhibit non-uniform clumps unlike in wild-type mice

retina photoreceptor degeneration ( J:128212 )

thin retina outer nuclear layer ( J:128212 )

retina degeneration ( J:128212 )

• whether light/dark reared or dark-only reared

nervous system

abnormal retina photoreceptor morphology ( J:128212 )

• the outer and inner segment boundaries are difficult to distinguish at 3, 6, and 8 weeks

abnormal photoreceptor outer segment morphology ( J:128212 )

• at 2 weeks, nascent rod outer segments exhibit non-uniform clumps unlike in wild-type mice

retina photoreceptor degeneration ( J:128212 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 4		DOID:0110372	OMIM:613731	J:128212

Genotype
MGI:3046195

ht3

• Allelic Composition: Rho^{tm2(RHO/GFP)Jhw}/Rho⁺
• Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyr^c * FVB)

vision/eye

retina degeneration ( J:91038 )

• mild retinal degeneration is seen with the number of nuclei in the outer nuclear layer being reduced to about 50% wild-type

Genotype
MGI:3046197

cx4

• Allelic Composition: Pde6b^rd1/Pde6b^rd1; Rho^{tm2(RHO/GFP)Jhw}/Rho⁺
• Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J * FVB) or (involves: 129S7/SvEvBrd * C57BL/6-Tyr^c * FVB)

vision/eye

retina degeneration ( J:91038 )

• retinas begin to degenerate within 9 days after birth

• GFP expression can clearly be seen as the retinas degenerate