Phenotypes associated with this allele

• Allele Symbol: Sycn^tm1Rja
• Allele Name: targeted mutation 1, Reinhard Jahn
• Allele ID: MGI:3046204
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sycn^tm1Rja/Sycn^tm1Rja	involves: 129P2/OlaHsd	MGI:3046208

Genotype
MGI:3046208

hm1

• Allelic Composition: Sycn^tm1Rja/Sycn^tm1Rja
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:74654 )

N • normal pancreatic morphology and normal basal secretory responses were noted; total protein content and levels appear normal

abnormal pancreas physiology ( J:74654 )

• the overall rate of protein synthesis was reduced

delayed pancreas regeneration ( J:74654 )

• after caerulein treatment, a delay in regeneration was noted compared to controls; 36 hours after treatment, inflammatory responses were still seen in mutant animals, while controls had largely recovered

increased susceptibility to induced pancreatitis ( J:74654 )

• treatment with caerulein induced a more severe pancreatitis reaction than in controls

immune system

increased susceptibility to induced pancreatitis ( J:74654 )

• treatment with caerulein induced a more severe pancreatitis reaction than in controls