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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fabp2tm1Mto
targeted mutation 1, Matthew J Toth
MGI:3046293
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fabp2tm1Mto/Fabp2tm1Mto B6.129S1-Fabp2tm1Mto MGI:3046295


Genotype
MGI:3046295
hm1
Allelic
Composition
Fabp2tm1Mto/Fabp2tm1Mto
Genetic
Background
B6.129S1-Fabp2tm1Mto
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fabp2tm1Mto mutation (0 available); any Fabp2 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• females on a high fat diet gain less weight (70%) than controls by 25 weeks of age
• weight gain about 110% over controls in males but not in females on a low fat diet
• 130% increase in weight by 25 weeks of age on a high fat diet in males
• in both sexes but plasma glucose remains normal
• plasma levels elevated in males but not in females
• females with lower plasma cholesterol levels than controls when on a high fat diet
• increased plasma triacylglycerol in males

adipose tissue
• males on a low fat diet with epididymal fat pad mass about 200% that of controls
• females on a high fat diet with uterine fat pad weights about 65% that of controls

liver/biliary system
• liver weight of males on a high fat diet increased 200% over controls
• female liver mass about 93% of controls on a high fat diet

renal/urinary system
• male kidney mass about 120% that of controls regardless of diet

growth/size/body
• females on a high fat diet gain less weight (70%) than controls by 25 weeks of age
• weight gain about 110% over controls in males but not in females on a low fat diet
• 130% increase in weight by 25 weeks of age on a high fat diet in males
• male kidney mass about 120% that of controls regardless of diet
• liver weight of males on a high fat diet increased 200% over controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory