digestive/alimentary system
N |
• mice do not develop intestinal polyps
|
Allele Symbol Allele Name Allele ID |
Hprt1tm1(CMV-cre)Brd targeted mutation 1, Allan Bradley MGI:3046308 |
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Summary |
4 genotypes
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|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice do not develop intestinal polyps
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• compared with ApcMin heterozygotes
|
• compared with ApcMin heterozygotes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
• some mice (5/208) survive to birth while all Nf1-null homozygotes expressing either Gt(ROSA)26Sortm1Fia or Hprt1tm1(CMV-cre)Brd die prior to birth
|
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• massively enlarged
|
|
• peripheral ganglia are massively enlarged in newborns
|
|
• enormous paraspinal masses arise from the dorsal root ganglia
|
|
• medulla is overgrown compared with wild-type, with cortical effacement and tumor-like medullary protrusion
|
|
• elevate Ras levels return to wild-type levels by E12.5 with expression of Gt(ROSA)26Sortm1Fia
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
• peripheral ganglia are massively enlarged in newborns
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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