Phenotypes associated with this allele

• Allele Symbol: Hprt1^{tm1(CMV-cre)Brd}
• Allele Name: targeted mutation 1, Allan Bradley
• Allele ID: MGI:3046308
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gpa33^tm1(GNAS)Wtsi/Gpa33^+ Hprt1^tm1(CMV-cre)Brd/?	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4889208
cn2	Apc^Min/Apc^+ Gpa33^tm1(GNAS)Wtsi/Gpa33^+ Hprt1^tm1(CMV-cre)Brd/?	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4889209
cn3	Gt(ROSA)26Sor^tm1Fia/Gt(ROSA)26Sor^+ Hprt1^tm1(CMV-cre)Brd/Hprt1^+ Nf1^tm1Fcr/Nf1^tm1Fcr	involves: 129S/SvEv * 129S/SvEvBrd	MGI:3689632
cn4	Gt(ROSA)26Sor^tm1Fia/Gt(ROSA)26Sor^tm1Fia Hprt1^tm1(CMV-cre)Brd/Hprt1^+ Nf1^tm1Fcr/Nf1^tm1Fcr	involves: 129S/SvEv * 129S/SvEvBrd	MGI:3689697

Genotype
MGI:4889208

cn1

• Allelic Composition: Gpa33^{tm1(GNAS)Wtsi}/Gpa33⁺; Hprt1^{tm1(CMV-cre)Brd}/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:168378 )

N • mice do not develop intestinal polyps

Genotype
MGI:4889209

cn2

• Allelic Composition: Apc^Min/Apc⁺; Gpa33^{tm1(GNAS)Wtsi}/Gpa33⁺; Hprt1^{tm1(CMV-cre)Brd}/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

neoplasm

increased intestinal adenoma incidence ( J:168378 )

• compared with Apc^Min heterozygotes

digestive/alimentary system

increased intestinal adenoma incidence ( J:168378 )

• compared with Apc^Min heterozygotes

Genotype
MGI:3689632

cn3

• Allelic Composition: Gt(ROSA)26Sor^tm1Fia/Gt(ROSA)26Sor⁺; Hprt1^{tm1(CMV-cre)Brd}/Hprt1⁺; Nf1^tm1Fcr/Nf1^tm1Fcr
• Genetic Background: involves: 129S/SvEv * 129S/SvEvBrd

mortality/aging

prenatal lethality, incomplete penetrance ( J:114455 )

♀ • some mice (5/208) survive to birth while all Nf1-null homozygotes expressing either Gt(ROSA)26Sor^tm1Fia or Hprt1^{tm1(CMV-cre)Brd} die prior to birth

nervous system

abnormal sympathetic ganglion morphology ( J:114455 )

♀ • massively enlarged

abnormal somatic sensory system morphology ( J:114455 )

♀ • peripheral ganglia are massively enlarged in newborns

abnormal dorsal root ganglion morphology ( J:114455 )

♀ • enormous paraspinal masses arise from the dorsal root ganglia

endocrine/exocrine glands

adrenal medulla hyperplasia ( J:114455 )

♀ • medulla is overgrown compared with wild-type, with cortical effacement and tumor-like medullary protrusion

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:114455 )

♀ • elevate Ras levels return to wild-type levels by E12.5 with expression of Gt(ROSA)26Sor^tm1Fia

Genotype
MGI:3689697

cn4

• Allelic Composition: Gt(ROSA)26Sor^tm1Fia/Gt(ROSA)26Sor^tm1Fia; Hprt1^{tm1(CMV-cre)Brd}/Hprt1⁺; Nf1^tm1Fcr/Nf1^tm1Fcr
• Genetic Background: involves: 129S/SvEv * 129S/SvEvBrd

nervous system

abnormal somatic sensory system morphology ( J:114455 )

♀ • peripheral ganglia are massively enlarged in newborns