Phenotypes associated with this allele

• Allele Symbol: Tg(Igk-V21-Bax)1967Bvn
• Allele Name: transgene insertion 1967, Brian Van Ness
• Allele ID: MGI:3046400
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Igha^tm1(Myc)Janz/Igha^+ Tg(Igk-V21-Bax)1967Bvn/0	involves: 129S1/Sv * C57BL/6 * FVB/N	MGI:3046405
cx2	Tg(IghMyc)22Bri/0 Tg(Igk-V21-Bax)1967Bvn/0	involves: C57BL/6 * FVB/N	MGI:3046406
tg3	Tg(Igk-V21-Bax)1967Bvn/0	involves: FVB/N	MGI:3046404

Genotype
MGI:3046405

cx1

• Allelic Composition: Igha^tm1(Myc)Janz/Igha⁺; Tg(Igk-V21-Bax)1967Bvn/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

enlarged spleen ( J:90901 )

• 8 week old double transgenic exhibit splenomegaly with massive accumulation of plasma cells in extrafollicular areas

mortality/aging

decreased tumor-free survival time ( J:90901 )

• survival of double transgenics is markedly decreased as a result of malignant plasma cell tumors

neoplasm

increased leukemia incidence ( J:90901 )

• in some cases plasma cell leukemia is seen

increased plasmacytoma incidence ( J:90901 )

• malignant plasma cell tumors develop rapidly with a mean onset of 135 days, are fully penetrant, proliferate vigorously, occur in multiple tissues including the spleen, bone marrow, and lymph nodes, and may have monocentric or multicentric origins

• bone sections from double transgenic mice with less advanced tumors show multifocal lesions of aberrant pleomorphic plasma cells next to diminished of dissolved osseous trabeculae

• pathalogical fractures of the long bones are seen in some double transgenic mice

hematopoietic system

abnormal B cell apoptosis ( J:90901 )

• B cell apoptosis is increased compared to normal B cells but decreased compared to B cells from Igh-2^tm1Janz single transgenics

enlarged spleen ( J:90901 )

• 8 week old double transgenic exhibit splenomegaly with massive accumulation of plasma cells in extrafollicular areas

abnormal plasma cell morphology ( J:90901 )

• plasma cells participate in cell cycling unlike in normal mice

increased plasma cell number ( J:90901 )

• the bone marrow and spleen contain on average 42% and 34% plasma cells, respectively, compared to less than 2% in normal mice

increased IgG level ( J:90901 )

• elevation of IgG accompanied the increase in plasma cell numbers

increased IgM level ( J:90901 )

• elevation of IgM accompanied the increase in plasma cell numbers

immune system

abnormal B cell apoptosis ( J:90901 )

• B cell apoptosis is increased compared to normal B cells but decreased compared to B cells from Igh-2^tm1Janz single transgenics

enlarged spleen ( J:90901 )

• 8 week old double transgenic exhibit splenomegaly with massive accumulation of plasma cells in extrafollicular areas

abnormal plasma cell morphology ( J:90901 )

• plasma cells participate in cell cycling unlike in normal mice

increased plasma cell number ( J:90901 )

• the bone marrow and spleen contain on average 42% and 34% plasma cells, respectively, compared to less than 2% in normal mice

increased IgG level ( J:90901 )

• elevation of IgG accompanied the increase in plasma cell numbers

increased IgM level ( J:90901 )

• elevation of IgM accompanied the increase in plasma cell numbers

cellular

abnormal B cell apoptosis ( J:90901 )

• B cell apoptosis is increased compared to normal B cells but decreased compared to B cells from Igh-2^tm1Janz single transgenics

Genotype
MGI:3046406

cx2

• Allelic Composition: Tg(IghMyc)22Bri/0; Tg(Igk-V21-Bax)1967Bvn/0
• Genetic Background: involves: C57BL/6 * FVB/N

mortality/aging

premature death ( J:89049 )

• 50% of double transgenics die of a lymphoproliferative disorder by 5.5 weeks

neoplasm

increased B cell derived lymphoma incidence ( J:89049 )

• multifocal to coalescent infiltrations of mononuclear cells with large round to polygonal hypochromatic nuclei are seen in the kidneys, spleen, lymph node, liver, ung, heart, thymus, pancreas, and sternal bone marrow

increased plasmacytoma incidence ( J:89049 )

• osteolytic lesions with cheets of pleomorphic plasmacytic cells adjacent to lysed osseous trabeculae are seen

hematopoietic system

enlarged spleen ( J:89049 )

• 4 - 6 week old double transgenic exhibit severe splenomegaly

increased transitional stage B cell number ( J:89049 )

• the number of immature/transitional B cells is increased

immune system

enlarged spleen ( J:89049 )

• 4 - 6 week old double transgenic exhibit severe splenomegaly

increased transitional stage B cell number ( J:89049 )

• the number of immature/transitional B cells is increased

liver/biliary system

abnormal liver morphology ( J:89049 )

• multiple beige nodules up to 2 mm in diameter are seen

growth/size/body

enlarged spleen ( J:89049 )

• 4 - 6 week old double transgenic exhibit severe splenomegaly

Genotype
MGI:3046404

tg3

• Allelic Composition: Tg(Igk-V21-Bax)1967Bvn/0
• Genetic Background: involves: FVB/N

hematopoietic system

increased transitional stage B cell number ( J:89049 )

• the number of immature/transitional B cells is increased

abnormal plasma cell morphology ( J:89049 )

• plasma cell foci are seen in the kidney, bone marrow and other lymphoid tissues

increased immunoglobulin level ( J:89049 )

• in response to a T cell independent antigen transgenic mice produce 65% more specific Igs compared to littermate controls

increased IgA level ( J:89049 )

• IgA serum levels are increased

increased IgE level ( J:89049 )

• IgE serum levels are increased

increased IgG level ( J:89049 , J:90901 )

• a moderate elevation of 3 isotypes of IgG is seen (J:90901)

increased IgG1 level ( J:89049 )

• serum levels are increased

increased IgG2a level ( J:89049 )

• serum levels are increased

increased IgM level ( J:89049 )

• IgM serum levels are increased

homeostasis/metabolism

increased urine protein level ( J:89049 )

• some transgenic mice have detectable levels of Ig proteins in their urine

immune system

increased transitional stage B cell number ( J:89049 )

• the number of immature/transitional B cells is increased

abnormal plasma cell morphology ( J:89049 )

• plasma cell foci are seen in the kidney, bone marrow and other lymphoid tissues

increased immunoglobulin level ( J:89049 )

• in response to a T cell independent antigen transgenic mice produce 65% more specific Igs compared to littermate controls

increased IgA level ( J:89049 )

• IgA serum levels are increased

increased IgE level ( J:89049 )

• IgE serum levels are increased

increased IgG level ( J:89049 , J:90901 )

• a moderate elevation of 3 isotypes of IgG is seen (J:90901)

increased IgG1 level ( J:89049 )

• serum levels are increased

increased IgG2a level ( J:89049 )

• serum levels are increased

increased IgM level ( J:89049 )

• IgM serum levels are increased

renal/urinary system

increased urine protein level ( J:89049 )

• some transgenic mice have detectable levels of Ig proteins in their urine

abnormal kidney morphology ( J:89049 )

• multiple perivascular foci of lymphocytes are seen in the kidney

renal cast ( J:89049 )

• hyaline renal tubular casts presumably made of Ig proteins are found