Phenotypes associated with this allele

• Allele Symbol: Id3^tm1Cmu
• Allele Name: targeted mutation 1, Cornelis Murre
• Allele ID: MGI:3046425
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Id3^tm1Cmu/Id3^tm1Cmu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3046426

Genotype
MGI:3046426

hm1

• Allelic Composition: Id3^tm1Cmu/Id3^tm1Cmu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:59969 )

• the total number of thymocytes is unchanged however the percent and total number of CD4 single positive cells is significantly decreased and the percent and total number of CD8 single positive cells is slightly decreased

• after 5 generations of backcrossing onto a C57BL/6J background slightly increased compared to wild-type

abnormal double-positive T cell morphology ( J:59969 )

• a small but consistent increase in CD5 expression is seen compared to wild-type littermates

immune system

abnormal T cell differentiation ( J:59969 )

• after 5 generations of backcrossing onto a C57BL/6J background slightly increased compared to wild-type

• the total number of thymocytes is unchanged however the percent and total number of CD4 single positive cells is significantly decreased and the percent and total number of CD8 single positive cells is slightly decreased

abnormal double-positive T cell morphology ( J:59969 )

• a small but consistent increase in CD5 expression is seen compared to wild-type littermates