Phenotypes associated with this allele

• Allele Symbol: Ung^tm1Mend
• Allele Name: targeted mutation 1, Matthias Endres
• Allele ID: MGI:3046503
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ung^tm1Mend/Ung^tm1Mend	involves: 129S4/SvJae * BALB/c	MGI:3046508

Genotype
MGI:3046508

hm1

• Allelic Composition: Ung^tm1Mend/Ung^tm1Mend
• Genetic Background: involves: 129S4/SvJae * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cellular sensitivity to oxidative stress ( J:90910 )

• homozygous MEF and primary cultures of cortical neurons are significantly more vulnerable to acute oxidative stress induced cell death

nervous system

increased susceptibility to ischemic brain injury ( J:90910 )

• 72 hours after 20 minute long middle cerebral artery occlusion the volume of lesions formed in the brains of homozygous mice are larger (greater than 230%) and include both cortical tissue and striatum compared to wild-type and heterozygous littermates

• the density of viable neurons within a lesion is decreased in homozygous mice

• sensory-motor deficits are more severe in homozygous mice compared to wild-type and heterozygous littermates

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:90910 )

• 72 hours after 20 minute long middle cerebral artery occlusion the volume of lesions formed in the brains of homozygous mice are larger (greater than 230%) and include both cortical tissue and striatum compared to wild-type and heterozygous littermates

• the density of viable neurons within a lesion is decreased in homozygous mice

• sensory-motor deficits are more severe in homozygous mice compared to wild-type and heterozygous littermates