Analysis Tools
skeleton
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• X-ray examination of the ankles of homozygous mutants shows normal, unfused carpal and tarsal bones
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• homozygous mutant mice present with permanently flexed ankles that cannot be straightened with a fair amount of pressure
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cardiovascular system
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• at necropsy, two 49 week-old female homozygotes were found to have thin-walled hearts
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muscle
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• at necropsy, two 49 week-old female homozygotes were found to have thin-walled hearts
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• at necropsy, an 8 month-old homozygous mutant female lacked muscle on the trunk and long bones
• two homozygous female mice necropsied at 49 weeks had atrophic muscle fibers in the skeletal muscles of the head
• two homozygous mutant female mice necropsied at 49 weeks exhibited myopathy of the extensors of the ankle (tarsal extensors) and less severe myopathy of the wrist (carpal) extensors
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• at necropsy, two 49 week-old female homozygous mutant mice exhibited dystrophy of the gastrocnemus and of the equivalent muscle of the forelimb
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reproductive system
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• two homozygous mutant female mice necropsied at 49 weeks exhibited thinning of the uterine wall muscles
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limbs/digits/tail
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• at necropsy, two 49 week-old female homozygous mutant mice exhibited dystrophy of the gastrocnemus and of the equivalent muscle of the forelimb
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