Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-cre)1Lin
• Allele Name: transgene insertion 1, Jonas Lindeberg
• Allele ID: MGI:3046554
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Psmc1^tm1Maye/Psmc1^tm1Maye Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-cre)1Lin/0	involves: 129 * C57BL/6 * CD-1	MGI:3809773

Genotype
MGI:3809773

cn1

• Allelic Composition: Psmc1^tm1Maye/Psmc1^tm1Maye; Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-cre)1Lin/0
• Genetic Background: involves: 129 * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:138991 )

• die at 3-4 months of age

growth/size/body

postnatal growth retardation ( J:138991 )

• subtle growth retardation starting 5 weeks of age and becoming statistically significant by 8 weeks

behavior/neurological

abnormal spatial learning ( J:138991 )

• obvious spatial learning deficits in the Morris water maze at 8 weeks

abnormal eating behavior ( J:138991 )

• lack interest in locating food at 3-4 months of age

abnormal fear/anxiety-related behavior ( J:138991 )

• significantly more anxious in open-field analysis at 6 weeks

nervous system

increased neuron apoptosis ( J:138991 )

enlarged brain ventricles ( J:138991 )

• expansion of the ventricular cavities accompanying atrophy of the forebrain

loss of cortex neurons ( J:138991 )

• extensive neuronal loss by 8 weeks

thin cerebral cortex ( J:138991 )

forebrain atrophy ( J:138991 )

• significant progressive atrophy of the forebrain

gliosis ( J:138991 )

• extensive gliosis as a result of the neuronal damage

alpha-synuclein inclusion body ( J:138991 )

• numerous eosinophilic intraneuronal paranuclear inclusions, containing ubiquitin, alpha-synuclein, and p62, similar to Lewy bodies

neurodegeneration ( J:138991 )

• neurodegeneration was evident in neurons expressing Tg(Camk2a-tTA)1Mmay in forebrain, hippocampus, striatum, and amygdala

cellular

increased neuron apoptosis ( J:138991 )