All Phenotypes Bub1b<tm1.1Jvd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bub1b^tm1.1Jvd
targeted mutation 1.1, Jan M A van Deursen
MGI:3046581

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bub1b^tm1.1Jvd/Bub1b^tm1.1Jvd	involves: 129S6/SvEvTac	MGI:3046585
ht2	Bub1b^tm1.1Jvd/Bub1b⁺	involves: 129S6/SvEvTac	MGI:3620042
ht3	Bub1b^tm1.1Jvd/Bub1b⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:6478927
ht4	Bub1b^tm1Jvd/Bub1b^tm1.1Jvd	involves: 129S6/SvEvTac	MGI:3046584
ht5	Bub1b^tm1Jvd/Bub1b^tm1.1Jvd	involves: 129S6/SvEvTac * C57BL/6	MGI:6478930

Allelic Composition	Bub1b^tm1.1Jvd/Bub1b^tm1.1Jvd
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1b^tm1.1Jvd mutation (0 available); any Bub1b mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:91128 )

• early embryonic lethality

Allelic Composition	Bub1b^tm1.1Jvd/Bub1b⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1b^tm1.1Jvd mutation (0 available); any Bub1b mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:194926 )

• reduced median (90 vs. 102 weeks) without a reduction in maximum lifespan

cellular

abnormal cell cycle checkpoint function ( J:105717 )

• after nocodazole treatment the time for 50% of cells to exit prometaphase arrest is reduced to 3.8 hours compared to 7.2 hours for wild-type MEFs

Allelic Composition	Bub1b^tm1.1Jvd/Bub1b⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1b^tm1.1Jvd mutation (0 available); any Bub1b mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:293084 )

• mice have a modest, but significant, reduction in lifespan

• however, mice show no evidence of accelerated aging phenotypes

cellular

aneuploidy ( J:293084 )

• MEFs show an elevation in aneuploidy

abnormal mitosis ( J:293084 )

• MEFs exhibit premature chromatid separation

• MEFs exhibit small, but significant, increase in chromosome segregation errors; both spindle assembly checkpoint and attachment error correction machinery are impaired

abnormal mitotic spindle assembly checkpoint ( J:293084 )

• spindle assembly checkpoint is impaired in MEFs

neoplasm

neoplasm ( J:293084 )

N	• incidence and spectrum of spontaneous tumors are similar to wild-type

increased tumor growth/size ( J:293084 )

• DMBA-treated mice show no increase in lung tumor incidence, however, lung tumor multiplicity and size are increased

decreased tumor latency ( J:293084 )

• although incidence and spectrum of spontaneous tumors are similar to wild-type, tumor latencies are reduced (741 days versus 886 days in wild-type mice)

• lymphomas which develop with reduced latencies contain more mitotic cells than lymphomas from wild-type mice

Allelic Composition	Bub1b^tm1Jvd/Bub1b^tm1.1Jvd
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1b^tm1.1Jvd mutation (0 available); any Bub1b mutation (59 available)
Bub1b^tm1Jvd mutation (0 available); any Bub1b mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:91128 )

• mutants die within a few hours of birth apparently from respiratory insufficiency

Allelic Composition	Bub1b^tm1Jvd/Bub1b^tm1.1Jvd
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:293084 )

• mice fail to thrive and die within 18 hours after birth

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