Phenotypes associated with this allele

• Allele Symbol: Crebbp^tm1Few
• Allele Name: targeted mutation 1, Fredric E Wondisford
• Allele ID: MGI:3046630
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crebbp^tm1Few/Crebbp^tm1Few	Not Specified	MGI:3046631
ht2	Crebbp^tm1Few/Crebbp^+	Not Specified	MGI:3046632

Genotype
MGI:3046631

hm1

• Allelic Composition: Crebbp^tm1Few/Crebbp^tm1Few
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:91133 )

• average islet mass is significantly greater in mutants possibly to compensate for decreased insulin secretion per gram DNA

homeostasis/metabolism

abnormal glucose homeostasis ( J:91133 )

• fasting mutants show an enhanced response to glucagon indicating increased gluconeogenesis

increased circulating glucose level ( J:91133 )

• increased fasting and fed blood glucose levels are seen

• hepatic glucose output is increased

decreased circulating glucagon level ( J:91133 )

• lower basal serum glucagon levels are seen

increased circulating insulin level ( J:91133 )

• serum insulin is increased in intraperitoneal glucose tolerance tests and in fed mutants compared to wild-type mice

impaired glucose tolerance ( J:91133 )

• mutants display glucose intolerance associated with increased serum insulin

increased liver glycogen level ( J:91133 )

• liver glycogen levels are not decreased after fasting

liver/biliary system

increased liver glycogen level ( J:91133 )

• liver glycogen levels are not decreased after fasting

Genotype
MGI:3046632

ht2

• Allelic Composition: Crebbp^tm1Few/Crebbp⁺
• Genetic Background: Not Specified

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:91133 )

homeostasis/metabolism

abnormal glucose homeostasis ( J:91133 )

• fasting mutants show an enhanced response to glucagon indicating increased gluconeogenesis

increased circulating glucose level ( J:91133 )

• increased fasting and fed blood glucose levels are seen

• hepatic glucose output is increased

decreased circulating glucagon level ( J:91133 )

• lower basal serum glucagon levels are seen

increased circulating insulin level ( J:91133 )

• serum insulin is increased in intraperitoneal glucose tolerance tests and in fed mutants compared to wild-type mice

impaired glucose tolerance ( J:91133 )

• mutants display glucose intolerance associated with increased serum insulin

increased liver glycogen level ( J:91133 )

• liver glycogen levels are not decreased after fasting

insulin resistance ( J:91133 )

• fasting mutants show insulin resistance compared to wild-type mice

liver/biliary system

increased liver glycogen level ( J:91133 )

• liver glycogen levels are not decreased after fasting