Phenotypes associated with this allele

• Allele Symbol: l4Jus25
• Allele Name: lethal, Chr 4, Justice 25
• Allele ID: MGI:3046735
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	l4Jus25/l4Jus25	involves: 129S7/SvEvBrd * C57BL/6	MGI:3846905
hm2	l4Jus25/l4Jus25	Not Specified	MGI:3047630

Genotype
MGI:3846905

hm1

• Allelic Composition: l4Jus25/l4Jus25
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size and cardiovascular defects in l4Jus25/l4Jus25 embryos

mortality/aging

premature death ( J:148802 )

• surviving mice are unhealthy and die shortly after weaning

postnatal lethality, incomplete penetrance ( J:148802 )

• few mice are observed at weaning

embryonic lethality during organogenesis, incomplete penetrance ( J:148802 )

• most mice die between E9.5 and E12.5

cardiovascular system

abnormal cardiovascular system morphology ( J:148802 )

abnormal heart development ( J:148802 )

• at E10.5

pericardial edema ( J:148802 )

• at E10.5

embryo

decreased embryo size ( J:148802 )

growth/size/body

decreased embryo size ( J:148802 )

homeostasis/metabolism

pericardial edema ( J:148802 )

• at E10.5

Genotype
MGI:3047630

hm2

• Allelic Composition: l4Jus25/l4Jus25
• Genetic Background: Not Specified

mortality/aging

preweaning lethality, complete penetrance ( J:89098 )

• animals die before P21; stage not determined