All Phenotypes Pip4k2b<Gt(Betageo)1Lca> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pip4k2b^{Gt(Betageo)1Lca}
gene trap 1, Lewis C Cantley
MGI:3046749

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pip4k2b^{Gt(Betageo)1Lca}/Pip4k2b^{Gt(Betageo)1Lca}	involves: 129S/SvEv * C57BL/6	MGI:3046750
cx2	Pip4k2b^{Gt(Betageo)1Lca}/Pip4k2b^{Gt(Betageo)1Lca} Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * 129S5/SvEvBrd	MGI:5568932
cx3	Pip4k2a^tm1.2Lca/Pip4k2a^tm1.2Lca Pip4k2b^{Gt(Betageo)1Lca}/Pip4k2b⁺ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S/SvEv * 129S2/SvPas * 129S5/SvEvBrd	MGI:5568940
cx4	Pip4k2a^tm1.2Lca/Pip4k2a^tm1.2Lca Pip4k2b^{Gt(Betageo)1Lca}/Pip4k2b^{Gt(Betageo)1Lca}	involves: 129S/SvEv * 129S5/SvEvBrd	MGI:5568937
cx5	Pip4k2a^tm1.2Lca/Pip4k2a⁺ Pip4k2b^{Gt(Betageo)1Lca}/Pip4k2b^{Gt(Betageo)1Lca}	involves: 129S/SvEv * 129S5/SvEvBrd	MGI:5568938

Allelic Composition	Pip4k2b^{Gt(Betageo)1Lca}/Pip4k2b^{Gt(Betageo)1Lca}
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pip4k2b^{Gt(Betageo)1Lca} mutation (0 available); any Pip4k2b mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:91023 )

• homozygous mice were produced from intercrossed heterozygotes at a slightly less than expected frequency (16% as opposed to 25%)

adipose tissue

decreased total body fat amount ( J:91023 )

• body fat was normal at 10 weeks of age while males became leaner as they aged

• females continued to have a normal body fat content at all ages

• both sexes remained lean on a high fat diet

growth/size/body

decreased body weight ( J:91023 )

• 15-25% lighter than normal before weaning

• females are about 10% lighter than normal as adults while males become 30% ligher than normal by 18 weeks of age

homeostasis/metabolism

abnormal circulating insulin level ( J:91023 )

• less than normal levels of insulin are produced during glucose tolerance tests

increased insulin sensitivity ( J:91023 )

• hypersensitive to insulin

• sensitivity increasing with age

limbs/digits/tail

short femur ( J:91023 )

• at 10 weeks of age, femurs are 7.3% +/- 0.7% shorter than controls

skeleton

short femur ( J:91023 )

• at 10 weeks of age, femurs are 7.3% +/- 0.7% shorter than controls

abnormal vertebral spinous process morphology ( J:91023 )

• spines were shorter than normal

decreased bone mineral density ( J:91023 )

• 10 week old male mice have 9.5% lower bone mineral density than controls

Allelic Composition	Pip4k2b^{Gt(Betageo)1Lca}/Pip4k2b^{Gt(Betageo)1Lca} Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * 129S5/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pip4k2b^{Gt(Betageo)1Lca} mutation (0 available); any Pip4k2b mutation (34 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:205288 )

• lethality by E12.5

embryo

open neural tube ( J:205288 )

• failure of neural tube closure

nervous system

open neural tube ( J:205288 )

• failure of neural tube closure

exencephaly ( J:205288 )

Allelic Composition	Pip4k2a^tm1.2Lca/Pip4k2a^tm1.2Lca Pip4k2b^{Gt(Betageo)1Lca}/Pip4k2b⁺ Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * 129S5/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pip4k2a^tm1.2Lca mutation (0 available); any Pip4k2a mutation (16 available)
Pip4k2b^{Gt(Betageo)1Lca} mutation (0 available); any Pip4k2b mutation (34 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:205288 )

• mice show a dramatic reduction in tumor formation and increased survival compared to single Trp53 homozygotes

Allelic Composition	Pip4k2a^tm1.2Lca/Pip4k2a^tm1.2Lca Pip4k2b^{Gt(Betageo)1Lca}/Pip4k2b^{Gt(Betageo)1Lca}
Genetic Background	involves: 129S/SvEv * 129S5/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:205288 )

• pups look normal at birth and are able to suckle, but die within 12 hours of birth

Allelic Composition	Pip4k2a^tm1.2Lca/Pip4k2a⁺ Pip4k2b^{Gt(Betageo)1Lca}/Pip4k2b^{Gt(Betageo)1Lca}
Genetic Background	involves: 129S/SvEv * 129S5/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:205288 )

• mice are born at Mendelian ratios with normal appearance and weight, however about half die within 12 hours after birth

growth/size/body

decreased body weight ( J:205288 )

• surviving adults are only 50% the weight of wild-type mice

postnatal growth retardation ( J:205288 )

• surviving mice are growth retarded

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