Analysis Tools|
Allele Symbol Allele Name Allele ID |
Rpl5Skax23-Jus skeletal/axial 23, Monica J Justice MGI:3046775 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• associated with severe pancytopenia
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• some mice are dead at E14.5
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• fewer than expected mice are born
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• some mice are dead at E12.5
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• in some mice at E12.5
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• at E14.5 but less prominent than at E12.5
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• at birth
• however, white blood cell and platelet counts were normal in some mice and adult mice exhibit no anemia or
hematopoietic defects
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• reduced in fetal livers at E14.5
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• in one mouse that died during the postnatal period
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• severe
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• in one mouse
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• in some mice
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• at E12.5 and E14.5 with fewer Ter119+ cells
• however, adult mice exhibit normal liver cellularity
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• in some mice at E12.5
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• in newborn mice
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• at birth with no evidence of endochondral ossification in the lower caudal vertebrae
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• in newborn mice
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• in newborn mice
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| N |
• newborn mice exhibit normal craniofacial morphology
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• in newborn mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Diamond-Blackfan anemia 6 | DOID:0111879 |
OMIM:612561 |
J:330162 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• described as a loop tail; low penetrance with 3 of 19 at N1 exhibiting, after an outcross to 129S/SvEv
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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