Phenotypes associated with this allele

• Allele Symbol: Tg(Myh7-cre)1Zli
• Allele Name: transgene insertion 1, Zhenlin Li
• Allele ID: MGI:3046780
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Srf^tm1Zli/Srf^tm1Zli Tg(Myh7-cre)1Zli/0	involves: 129/Sv * C57BL/6	MGI:3046783

Genotype
MGI:3046783

cn1

• Allelic Composition: Srf^tm1Zli/Srf^tm1Zli; Tg(Myh7-cre)1Zli/0
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:91025 )

• mutant embryos begin to die around E10.5 however at E9.5 only 20% cre expressing homozygous embryos were found, rather than the expected 25%

cardiovascular system

abnormal myocardial fiber morphology ( J:91025 )

• the cytoplasmic volume of the cardiomyocytes is reduced

trabecula carnea hypoplasia ( J:91025 )

• the trabeculae are thinner and less-abundant

disorganized myocardium ( J:91025 )

• at E11.5 the myocardial wall is severely disorganized

thin myocardium ( J:91025 )

• at E11.5 the myocardial wall is severely disorganized with varying degrees of ventricular atrophy, the thickness of the compact layer is significantly reduced, and the atrial wall thickness is severely reduced

thin interventricular septum ( J:91025 )

• the interventricular septum is thinner and disorganized

abnormal heart shape ( J:91025 )

• the lumens of the right and left atria are significantly enlarged

internal hemorrhage ( J:91025 )

• starting at E10.5 embryos develop severe hemorrages in and around the cardiac and ventral body wall regions

cellular

abnormal apoptosis ( J:91025 )

• a dramatic increase in apoptotic cells is seen at E11.5 in the heart, limb buds, epidermis, and vessels

growth/size/body

embryonic growth retardation ( J:91025 )

• by E13.5 only growth-retarded or resorbed embryos are found

muscle

abnormal myocardial fiber morphology ( J:91025 )

• the cytoplasmic volume of the cardiomyocytes is reduced

trabecula carnea hypoplasia ( J:91025 )

• the trabeculae are thinner and less-abundant

disorganized myocardium ( J:91025 )

• at E11.5 the myocardial wall is severely disorganized

thin myocardium ( J:91025 )

• at E11.5 the myocardial wall is severely disorganized with varying degrees of ventricular atrophy, the thickness of the compact layer is significantly reduced, and the atrial wall thickness is severely reduced

embryo

embryonic growth retardation ( J:91025 )

• by E13.5 only growth-retarded or resorbed embryos are found