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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxb1tm7Mrc
targeted mutation 7, Mario R Capecchi
MGI:3046794
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hoxb1tm7Mrc/Hoxb1tm7Mrc Not Specified MGI:3050405
cn2
 		Hoxb1tm5Mrc/Hoxb1tm7Mrc
Tfap2atm1(cre)Moon/Tfap2a+ 		involves: 129S1/Sv * 129X1/SvJ MGI:3050415
cn3
 		Hoxb1tm5Mrc/Hoxb1tm7Mrc
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		Not Specified MGI:3050407


Genotype
MGI:3050405
hm1
Allelic
Composition		 Hoxb1tm7Mrc/Hoxb1tm7Mrc
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb1tm7Mrc mutation (0 available); any Hoxb1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:91364 )
• mutants are fertile and indistinguishable from wild-type mice




Genotype
MGI:3050415
cn2
Allelic
Composition		 Hoxb1tm5Mrc/Hoxb1tm7Mrc
Tfap2atm1(cre)Moon/Tfap2a+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb1tm5Mrc mutation (0 available); any Hoxb1 mutation (24 available)
Hoxb1tm7Mrc mutation (0 available); any Hoxb1 mutation (24 available)
Tfap2atm1(cre)Moon mutation (1 available); any Tfap2a mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:91364 )
N
• no behavioral abnormalities are seen

nervous system
decreased motor neuron number ( J:91364 )
• the average number of motor neurons is significantly reduced in mutants compared to wild-type mice although not to the same extent as in compound heterozygous mutants carrying Tg(Wnt1-cre)11Rth




Genotype
MGI:3050407
cn3
Allelic
Composition		 Hoxb1tm5Mrc/Hoxb1tm7Mrc
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Hoxb1tm5Mrc mutation (0 available); any Hoxb1 mutation (24 available)
Hoxb1tm7Mrc mutation (0 available); any Hoxb1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal reflex ( J:91364 )
• some mutants are unable to move their ears
abnormal blinking ( J:91364 )
• some mutants are unable to blink their eyes
abnormal vibrissae reflex ( J:91364 )
• some mutants are unable to move their whiskers
paralysis ( J:91364 )
• 35% of mutants show total facial paralysis and another 10% show partial facial paralysis

nervous system
decreased motor neuron number ( J:91364 )
• increased motor neuron loss is seen from E14.5 to E16.5 when motor neuron pruning normally occurs resulting a significant decrease in the average number of motor neurons in mutants compared to wild-type mice
abnormal facial nerve morphology ( J:91364 )
• loss of VII th cranial nerve branches is seen
• at E12.5 the average number of axonal branch points is decreased




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory