Phenotypes associated with this allele

• Allele Symbol: Prkcd^tm1Msg
• Allele Name: targeted mutation 1, Robert O Messing
• Allele ID: MGI:3046799
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkcd^tm1Msg/Prkcd^tm1Msg	involves: 129X1/SvJ * C57BL/6J	MGI:3046859

Genotype
MGI:3046859

hm1

• Allelic Composition: Prkcd^tm1Msg/Prkcd^tm1Msg
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased neutrophil cell number ( J:91377 )

• 80% and 65% fewer neutrophils are found in the cerebral cortex and striatum, respectively, compared to wild-type mice

• no difference is seen in the number of neutrophils in the peripheral blood

abnormal neutrophil physiology ( J:91377 )

• in vitro neutrophil adhesion, migration, and superoxide anion release are reduced

nervous system

abnormal response to CNS ischemic injury ( J:91377 )

• infarct size is reduced by about 65% following transient but not after permanent middle cerebral artery occlusion

hematopoietic system

decreased neutrophil cell number ( J:91377 )

• 80% and 65% fewer neutrophils are found in the cerebral cortex and striatum, respectively, compared to wild-type mice

• no difference is seen in the number of neutrophils in the peripheral blood

abnormal neutrophil physiology ( J:91377 )

• in vitro neutrophil adhesion, migration, and superoxide anion release are reduced

homeostasis/metabolism

abnormal response to CNS ischemic injury ( J:91377 )

• infarct size is reduced by about 65% following transient but not after permanent middle cerebral artery occlusion