All Phenotypes Map3k5<tm1Hijo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k5^tm1Hijo/Map3k5^tm1Hijo	B6.129S4-Map3k5^tm1Hijo	MGI:3046845
hm2	Map3k5^tm1Hijo/Map3k5^tm1Hijo	involves: 129S4/SvJae * C57BL/6J	MGI:3046844
cn3	Map3k5^tm1Hijo/Map3k5^tm1Hijo Raf1^tm2Bacc/Raf1^tm2Bacc Tg(Myh6-cre)2182Mds/0	involves: C57BL/6J	MGI:3510548
cx4	Map3k5^tm1Hijo/Map3k5^tm1Hijo Map3k6^tm1Hijo/Map3k6^tm1Hijo	B6.129-Map3k6^tm1Hijo Map3k5^tm1Hijo	MGI:3844019

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:88195 )

N	• cardiac morphology and function are not different from controls

decreased response of heart to induced stress ( J:88195 )

• 4 weeks after thoracic transverse aortic constriction fractional shortening, left ventricular end diastolic internal dimension, and lung weight are not significantly different from sham operated controls unlike in wild type mice

• decrease in the number of apoptotic cells detected at 1 and 4 weeks after thoracic transverse aortic constriction compared to wild-type controls

• however, 1 week after thoracic transverse aortic constriction heart weight is increased similar to what is seen in wild-type controls and the degree of fibrosis is similar in both mutant and wild-type mice

abnormal response to cardiac infarction ( J:88195 )

• following myocardial infarction increases in left ventricular end diastolic and end systolic internal dimensions are decreased compared to wild-type controls

• following myocardial infarction the decrease in fractional shortening and replacement fibrosis are less than that in wild-type controls

• decrease in the number of apoptotic cells detected at 1 and 4 weeks after induced infarction compared to wild-type controls

homeostasis/metabolism

decreased response of heart to induced stress ( J:88195 )

• decrease in the number of apoptotic cells detected at 1 and 4 weeks after thoracic transverse aortic constriction compared to wild-type controls

abnormal response to cardiac infarction ( J:88195 )

• following myocardial infarction increases in left ventricular end diastolic and end systolic internal dimensions are decreased compared to wild-type controls

• following myocardial infarction the decrease in fractional shortening and replacement fibrosis are less than that in wild-type controls

• decrease in the number of apoptotic cells detected at 1 and 4 weeks after induced infarction compared to wild-type controls

decreased physiological sensitivity to xenobiotic ( J:148044 )

• primary keratinocytes are more resistant to DMBA induced apoptosis compared to wild-type cells

• hyperplasia following TPA exposure is milder than in wild type controls

Allelic Composition	Map3k5^tm1Hijo/Map3k5^tm1Hijo
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k5^tm1Hijo mutation (4 available); any Map3k5 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased sensitivity to induced cell death ( J:88612 )

• decrease in the induction of apoptosis by TNF, H2O2 or other oxidative stressors in MEFs

mortality/aging

mortality/aging ( J:251158 )

N	• following treatment with high doses of recombinant mouse TNF (mTNF), mice are only slightly protected from mTNF-induced lethality relative to wild-type controls

immune system

immune system phenotype ( J:251158 )

N	• mice are not significantly protected from TNF (mTNF)-induced mortality and hypothermia

Allelic Composition	Map3k5^tm1Hijo/Map3k5^tm1Hijo Raf1^tm2Bacc/Raf1^tm2Bacc Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k5^tm1Hijo mutation (4 available); any Map3k5 mutation (62 available)
Raf1^tm2Bacc mutation (2 available); any Raf1 mutation (117 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:93418 )

N	• heart size, morphology and function are not significantly different from wild-type unlike Raf1^tm2Bacc, Tg(Myhca-cre)2182Mds mutants

Allelic Composition	Map3k5^tm1Hijo/Map3k5^tm1Hijo Map3k6^tm1Hijo/Map3k6^tm1Hijo
Genetic Background	B6.129-Map3k6^tm1Hijo Map3k5^tm1Hijo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k5^tm1Hijo mutation (4 available); any Map3k5 mutation (62 available)
Map3k6^tm1Hijo mutation (3 available); any Map3k6 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:148044 )

• hyperplasia following TPA exposure is milder than in wild type controls or mice homozygous for Map3k6^tm1Hijo alone

neoplasm

neoplasm ( J:148044 )

N	• unlike mice homozygous for Map3k6^tm1Hijo alone, no increase in chemically induced skin tumorigenesis is detected

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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