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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Otx2tm5Sia
targeted mutation 5, Shinichi Aizawa
MGI:3046839
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Otx2tm5Sia/Otx2tm5Sia involves: C57BL/6NCrlj * CBA/JNCrlj MGI:3046975
ht2
 		Otx2tm1Sia/Otx2tm5Sia involves: C57BL/6NCrlj * CBA/JNCrlj MGI:3047000
cx3
 		Otx1tm1Sia/Otx1tm1Sia
Otx2tm5Sia/Otx2tm5Sia 		involves: C57BL/6NCrlj * CBA/JNCrlj MGI:3047002


Genotype
MGI:3046975
hm1
Allelic
Composition		 Otx2tm5Sia/Otx2tm5Sia
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm5Sia mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:91011 )
N
• forebrain and midbrain development appear normal




Genotype
MGI:3047000
ht2
Allelic
Composition		 Otx2tm1Sia/Otx2tm5Sia
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm1Sia mutation (1 available); any Otx2 mutation (50 available)
Otx2tm5Sia mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain development ( J:91011 )
• midbrain and forebrain development is impaired however the telencephalon appears normal
• at E15.5 the cerebellar primordium is expanded and the Fgf8 positive isthmic stripe is shifted rostrally
absent midbrain ( J:91011 )
• the midbrain is nearly absent
absent diencephalon ( J:91011 )
• the diencephalon is mostly absent




Genotype
MGI:3047002
cx3
Allelic
Composition		 Otx1tm1Sia/Otx1tm1Sia
Otx2tm5Sia/Otx2tm5Sia
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx1tm1Sia mutation (1 available); any Otx1 mutation (86 available)
Otx2tm5Sia mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain development ( J:91011 )
• midbrain and forebrain development is impaired however the telencephalon appears normal
• the Fgf8 positive isthmic stripe is absent
absent midbrain ( J:91011 )
• the mesencephalon is almost completely absent
absent diencephalon ( J:91011 )
• the diencephalon is almost completely absent




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory