Analysis Tools
mortality/aging
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• the condition of mutants begins to deteriorate around 8 weeks of age and the average life span is only 10 - 18 weeks
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behavior/neurological
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• mutants are unable to support their own weight in the hanging wire grip test
|
abnormal gait
(
J:91191
)
|
• walking track analysis indicates that mutants have an abnormal gait
|
|
• mutants have a shorter stride length
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cardiovascular system
|
• the distinct organization of contractile filaments is significantly reduced in mutants
|
small heart
(
J:91191
)
|
• at 6 weeks of age the heart is smaller than normal
|
endocrine/exocrine glands
small testis
(
J:91191
)
 |
• at 6 weeks of age the testes are smaller than normal
|
growth/size/body
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• mutant pups are the same size at birth however within a few days they are noticeably smaller than wild-type littermates
|
hematopoietic system
small spleen
(
J:91191
)
|
• at 6 weeks of age the spleen is smaller than normal
|
immune system
small spleen
(
J:91191
)
|
• at 6 weeks of age the spleen is smaller than normal
|
muscle
|
• the distinct organization of contractile filaments is significantly reduced in mutants
|
|
• at 6 weeks of age the limb musculature is less well developed
|
reproductive system
small testis
(
J:91191
)
|
|
• at 6 weeks of age the testes are smaller than normal
|
respiratory system
small lung
(
J:91191
)
|
• at 6 weeks of age the lungs are smaller than normal
|
