Phenotypes associated with this allele

• Allele Symbol: Mmp14^tm1Noda
• Allele Name: targeted mutation 1, Makoto Noda
• Allele ID: MGI:3046860
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp14^tm1Noda/Mmp14^tm1Noda	Not Specified	MGI:3046920
cx2	Mmp14^tm1Noda/Mmp14^+ Mmp2^tm1Ito/Mmp2^tm1Ito	Not Specified	MGI:3046923
cx3	Mmp14^tm1Noda/Mmp14^tm1Noda Mmp2^tm1Ito/Mmp2^tm1Ito	Not Specified	MGI:3046924

Genotype
MGI:3046920

hm1

• Allelic Composition: Mmp14^tm1Noda/Mmp14^tm1Noda
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:91198 )

• homozygous mutants are indistinguishable from wild-type littermates

Genotype
MGI:3046923

cx2

• Allelic Composition: Mmp14^tm1Noda/Mmp14⁺; Mmp2^tm1Ito/Mmp2^tm1Ito
• Genetic Background: Not Specified

growth/size/body

decreased body weight ( J:91198 )

• mutants weigh about 20% less than control littermates but are fertile

Genotype
MGI:3046924

cx3

• Allelic Composition: Mmp14^tm1Noda/Mmp14^tm1Noda; Mmp2^tm1Ito/Mmp2^tm1Ito
• Genetic Background: Not Specified

mortality/aging

neonatal lethality, complete penetrance ( J:91198 )

• neonates die within 10 minutes of birth

cardiovascular system

abnormal blood vessel morphology ( J:91198 )

• the proportion of vessels with a diameter greater than 30 nm is reduced

• many capillaries with minimal luminal opening are seen

growth/size/body

decreased birth weight ( J:91198 )

• neonates weigh about 10 - 30% less than Mmp2^tm1Ito single homozygotes

homeostasis/metabolism

cyanosis ( J:91198 )

• neonates appear cyanotic and have difficulty breathing

muscle

delayed muscle development ( J:91198 )

• more muscle fibers appear to be immature with central nuclei present and in vitro myotube formation is impaired

abnormal skeletal muscle morphology ( J:91198 )

• the back and intercostal muscles have shorter muscle fibers in an abnormal wavy pattern

thin diaphragm muscle ( J:91198 )

• the diaphragm is consistently thinner in double mutants compared to Mmp2^tm1Ito single homozygotes

skeleton

abnormal skeleton morphology ( J:91198 )

• the skull and bones are generally smaller

abnormal bone ossification ( J:91198 )

• ossification and growth plate vascularization are impaired