Phenotypes associated with this allele

• Allele Symbol: Capn3^{Gt(OST141731)Lex}
• Allele Name: gene trap OST141731, Lexicon Genetics
• Allele ID: MGI:3046866
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Capn3^Gt(OST141731)Lex/Capn3^Gt(OST141731)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3047138

Genotype
MGI:3047138

hm1

• Allelic Composition: Capn3^{Gt(OST141731)Lex}/Capn3^{Gt(OST141731)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:91206 )

• young mutant males are smaller than wild-type

muscle

abnormal muscle morphology ( J:91206 )

abnormal gastrocnemius morphology ( J:91206 )

• the slow fiber area is reduced by about 15%

• rare and small foci of necrosis and regeneration accompanied by inflammatory cells are seen

abnormal soleus morphology ( J:91206 )

• the fast and slow fiber areas are reduced about 28% and 21%, respectively

• rare and small foci of necrosis and regeneration accompanied by inflammatory cells are seen

abnormal tibialis anterior morphology ( J:91206 )

• rare and small foci of necrosis and regeneration accompanied by inflammatory cells are seen

abnormal A band morphology ( J:91206 )

• the A-bands of mutant sarcomeres are misaligned resulting in a ragged appearance

abnormal skeletal muscle fiber morphology ( J:91206 )

• abundant and disorganized mitochondria and lobulated fibers are seen

abnormal diaphragm morphology ( J:91206 )

• rare and small foci of necrosis and regeneration accompanied by inflammatory cells are seen

decreased skeletal muscle mass ( J:91206 )

• muscle mass is reduced in mutant mice

limbs/digits/tail

abnormal gastrocnemius morphology ( J:91206 )

• the slow fiber area is reduced by about 15%

• rare and small foci of necrosis and regeneration accompanied by inflammatory cells are seen

abnormal soleus morphology ( J:91206 )

• the fast and slow fiber areas are reduced about 28% and 21%, respectively

• rare and small foci of necrosis and regeneration accompanied by inflammatory cells are seen

abnormal tibialis anterior morphology ( J:91206 )

• rare and small foci of necrosis and regeneration accompanied by inflammatory cells are seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive limb-girdle muscular dystrophy type 2A		DOID:0110275	OMIM:253600	J:91206