Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(hREN)9Sig transgene insertion 9, Curt Sigmund MGI:3046926 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a resetting of the baroreflex control of heart rate to a higher pressure without changing the gain or sensitivity of the reflex
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following treatment with L-NAME and a high salt diet, all mice die
• mice on a high salt diet exhibit increased lethality associated with brain hemorrhages
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• 2 mice treated with both L-NAME and a high salt diet exhibited a dissecting aortic aneurysm in addition to hemorrhagic stroke unlike similarly treated wild-type mice
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• following treatment with L-NAME and a high salt diet, the heart weight to body weight ratio is increased compared to in similarly treated wild-type mice
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• following treatment with L-NAME and a high salt diet, 2 of 8 mice exhibit basal ganglia hemorrhages unlike wild-type mice
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• in all mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
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• in 4 of 8 mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
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• following treatment with L-NAME and a high salt diet
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• following treatment with a high salt diet, mice exhibit an increase in systolic blood pressure not observed in similarly treated wild-type mice
• mice exhibit a higher systolic blood pressure than wild-type mice
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• following treatment with L-NAME and a high salt diet, 2 of 8 mice exhibit basal ganglia hemorrhages unlike wild-type mice
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• in all mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
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• in 4 of 8 mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
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• following treatment with L-NAME and a high salt diet
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• following treatment with L-NAME and a high salt diet
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• following treatment with L-NAME and a high salt diet, the heart weight to body weight ratio is increased compared to in similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal blood pressure
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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