All Phenotypes Pycard<tm1Vmd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pycard^tm1Vmd
targeted mutation 1, Vishva M Dixit
MGI:3046932

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pycard^tm1Vmd/Pycard^tm1Vmd	B6.129-Pycard^tm1Vmd	MGI:5428937
hm2	Pycard^tm1Vmd/Pycard^tm1Vmd	involves: 129S1/Sv * 129X1/SvJ	MGI:3625289
hm3	Pycard^tm1Vmd/Pycard^tm1Vmd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5467383
hm4	Pycard^tm1Vmd/Pycard^tm1Vmd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:3047277
cn5	Gt(ROSA)26Sor^{tm1(OVAL/fla,GFP)Vnce}/Gt(ROSA)26Sor⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺ Pycard^tm1Vmd/Pycard^tm1Vmd	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6196858
cx6	Nlrp1a^Neut1/Nlrp1a^Neut1 Pycard^tm1Vmd/Pycard^tm1Vmd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5474286

Allelic Composition	Pycard^tm1Vmd/Pycard^tm1Vmd
Genetic Background	B6.129-Pycard^tm1Vmd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycard^tm1Vmd mutation (1 available); any Pycard mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage physiology ( J:160545 )

• improved bone marrow derived macrophage viability following infection with F. tularensis

decreased circulating interleukin-1 beta level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased circulating interleukin-18 level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

increased interferon-beta secretion ( J:160545 )

• in bone marrow derived macrophages stimulated by poly(dA:dT) or pcDNA3

decreased interleukin-1 beta secretion ( J:160545 , J:193522 )

• in LPS-primed bone marrow derived macrophages stimulated by S. typhimurium or dsDNA (J:160545)

• bone marrow derived macrophages do not secrete IL1B in response to F. tularensis (J:160545)

• from LPS-primed bone marrow-derived macrophages stimulated with E. coli, C. rodentium, C. cholera and CTB (J:193522)

increased tumor necrosis factor secretion ( J:160545 )

• in bone marrow derived macrophages stimulated by poly(dA:dT) or pcDNA3

decreased susceptibility to endotoxin shock ( J:193522 )

• mice treated with LPS challenge in a model of acute septic shock exhibit reduced serum levels of IL1b and IL18 compared with controls

• however, mice do not survive beyond 20 hours and serum levels of IL1a are increased

homeostasis/metabolism

decreased circulating interleukin-1 beta level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

decreased circulating interleukin-18 level ( J:193522 )

• in response to LPS challenge in a model of acute septic shock

hematopoietic system

abnormal macrophage physiology ( J:160545 )

• improved bone marrow derived macrophage viability following infection with F. tularensis

Allelic Composition	Pycard^tm1Vmd/Pycard^tm1Vmd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycard^tm1Vmd mutation (1 available); any Pycard mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-1 beta secretion ( J:106976 , J:124226 )

• unlike macrophages from wild-type mice, macrophages from Pycard-deficient mice do not release significant amounts of Il-1beta when primed with LPS and treated with nigericin or maitotoxin to deplete intracellular K+ (J:106976)

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), IL-1-beta release from peritoneal macrophages is impaired (J:124226)

decreased interleukin-18 secretion ( J:106976 )

• unlike macrophages from wild-type mice, macrophages from Pycard-deficient mice do not release significant amounts of Il-18 when primed with LPS and treated with nigericin or maitotoxin to deplete intracellular K+

abnormal response to infection ( J:106976 )

• macrophages from null mice show reduced or undetectable Il-1beta release and caspase-1 activation in culture when infected with Salmonella or Francisella and reduced or undetectable Il-18 release upon infection with Salmonella, S. aureus, Francisella or Listeria compared to wild-type macrophages

Allelic Composition	Pycard^tm1Vmd/Pycard^tm1Vmd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycard^tm1Vmd mutation (1 available); any Pycard mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:191239 )

N	• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit normal skin tumor formation

Allelic Composition	Pycard^tm1Vmd/Pycard^tm1Vmd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycard^tm1Vmd mutation (1 available); any Pycard mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-1 alpha secretion ( J:91292 )

• reduced release of Il1 alpha from toll-like receptor primed macrophage

decreased interleukin-1 beta secretion ( J:91292 )

• reduced release of Il1 beta from toll-like receptor primed macrophage

• significantly decreased production of Il-1beta in response to Salmonella typhimurium infection

decreased interleukin-18 secretion ( J:91292 )

• reduced release of Il18 from toll-like receptor primed macrophage

decreased inflammatory response ( J:91292 )

• enhanced survival after injection with normally lethal doses of lipopolysaccharide

Allelic Composition	Gt(ROSA)26Sor^{tm1(OVAL/fla,GFP)Vnce}/Gt(ROSA)26Sor⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺ Pycard^tm1Vmd/Pycard^tm1Vmd
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(OVAL/fla,GFP)Vnce} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Pycard^tm1Vmd mutation (1 available); any Pycard mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:260047 )

N	• mice show normal weight gain at 10 weeks of age

homeostasis/metabolism

increased circulating interferon-gamma level ( J:260047 )

• slight increase in IFN-gamma levels

increased circulating interleukin-6 level ( J:260047 )

• slight increase in IL-6 levels

increased circulating tumor necrosis factor level ( J:260047 )

• slight increase in TNF levels

immune system

immune system phenotype ( J:260047 )

N	• mice show no joint inflammation at 10 weeks of age, cytokine levels (such as IL-1 alpha, IL-1 beta, and MCP-1) are severely reduced, and the autoinflammatory disease seen in Gt(ROSA)26Sor^{tm1(OVAL/fla-GFP)Vnce} and Lyz2^tm1(cre)Ifo expressing mice is almost entirely ameliorated

increased circulating interferon-gamma level ( J:260047 )

• slight increase in IFN-gamma levels

increased circulating interleukin-6 level ( J:260047 )

• slight increase in IL-6 levels

increased circulating tumor necrosis factor level ( J:260047 )

• slight increase in TNF levels

Allelic Composition	Nlrp1a^Neut1/Nlrp1a^Neut1 Pycard^tm1Vmd/Pycard^tm1Vmd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp1a^Neut1 mutation (0 available); any Nlrp1a mutation (64 available)
Pycard^tm1Vmd mutation (1 available); any Pycard mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased neutrophil cell number ( J:191055 )

immune system

increased neutrophil cell number ( J:191055 )

abnormal inflammatory response ( J:191055 )

• lethal systemic inflammatory disease

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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