Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nlrc4tm1Vmd targeted mutation 1, Vishva M Dixit MGI:3046934 |
||||||||||||||||||||
| Summary |
4 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• caspase dependent cell death resulting from infection with Salmonella typhimurium reduced to minor levels
|
|
• negligible amounts of Il-1beta produced when infected with Salmonella typhimurium
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• macrophages from null mice exhibit almost undetectable Il-1beta release and no activation of caspase-1 in culture when infected with Salmonella, compared to wild-type or Cias- and Asc-deficient macrophages
|
|
• macrophages from null mice exhibit almost undetectable Il-1beta release and no activation of caspase-1 in culture when infected with Salmonella, compared to wild-type or Cias- and Asc-deficient macrophages
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• neutrophilic inflammation is not apparent
|
| N |
• mice exhibit normal joints
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• in LPS-primed bone marrow derived macrophages stimulated by S. typhimurium
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|
|
||
