Phenotypes associated with this allele

• Allele Symbol: En1^{tm1(Wnt1)Wrst}
• Allele Name: targeted mutation 1, Wolfgang Wurst
• Allele ID: MGI:3046939
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	En1^tm1(Wnt1)Wrst/En1^tm1(Wnt1)Wrst	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3047082
ht2	En1^tm1(Wnt1)Wrst/En1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3047083

Genotype
MGI:3047082

hm1

• Allelic Composition: En1^{tm1(Wnt1)Wrst}/En1^{tm1(Wnt1)Wrst}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:91004 )

• homozygous mutants die at P0

nervous system

increased inferior colliculus size ( J:91004 )

• the volume of the inferior colliculi is increased

• this increase is more pronounced than in En1^{tm1(Wnt1)Wrst} heterozygotes

Genotype
MGI:3047083

ht2

• Allelic Composition: En1^{tm1(Wnt1)Wrst}/En1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

cellular

abnormal cell cycle ( J:91004 )

• cell cycle length is decreased from 21.1 to 19.9 hours

increased cell proliferation ( J:91004 )

• from E11.5 to E18.5 proliferation of neural progenitors in the inferior colliculi is increased, however no change in tumor formation is seen

nervous system

increased inferior colliculus size ( J:91004 )

• the volume of the inferior colliculi is increased 4.8 fold

• this enlargement can first be detected at E13

abnormal hindbrain morphology ( J:91004 )

• there is a transient increase in the size of the lateral regions of the ventrorostral hindbrain from E10 until E15

abnormal cerebellum morphology ( J:91004 )

• enlargement of the granular cell layer resulting in a slightly undulated appearance of the rostral folia is seen in horizontal sections from adult cerebelli