Phenotypes associated with this allele

• Allele Symbol: Hyou1^tm1Oga
• Allele Name: targeted mutation 1, Satoshi Ogawa
• Allele ID: MGI:3046998
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hyou1^tm1Oga/Hyou1^tm1Oga	involves: 129S1/Sv * C57BL/6	MGI:3050241
ht2	Hyou1^tm1Oga/Hyou1^+	involves: 129S1/Sv	MGI:3050239
ht3	Hyou1^tm1Oga/Hyou1^+	involves: 129S1/Sv * C57BL/6	MGI:3050240
cx4	Hyou1^tm1Oga/Hyou1^+ Sil1^Gt(RST462)Byg/Sil1^Gt(RST462)Byg	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J	MGI:4417864

Genotype
MGI:3050241

hm1

• Allelic Composition: Hyou1^tm1Oga/Hyou1^tm1Oga
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:91396 )

• no homozygous mutant pups are found at birth

Genotype
MGI:3050239

ht2

• Allelic Composition: Hyou1^tm1Oga/Hyou1⁺
• Genetic Background: involves: 129S1/Sv

nervous system

increased susceptibility to ischemic brain injury ( J:91007 )

• 1 hour but not 3 hours after occlusion of the middle cerebral artery, cortical infarct volume was significantly larger in heterozygotes compared to mice carrying Tg(PDGFB-Hyou1)

abnormal substantia nigra pars compacta morphology ( J:117737 )

• elevation of GPR37 levels by injection adeno-viral expression vectors results in increased dopaminergic neuronal cell death of cells in the substantia nigra pars compacta

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:91007 )

• 1 hour but not 3 hours after occlusion of the middle cerebral artery, cortical infarct volume was significantly larger in heterozygotes compared to mice carrying Tg(PDGFB-Hyou1)

Genotype
MGI:3050240

ht3

• Allelic Composition: Hyou1^tm1Oga/Hyou1⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:91396 )

• kainate causes enhanced excitotoxicity induced neuronal cell death in mutants compared to wild-type mice

nervous system

increased susceptibility to neuronal excitotoxicity ( J:91396 )

• kainate causes enhanced excitotoxicity induced neuronal cell death in mutants compared to wild-type mice

cellular

increased susceptibility to neuronal excitotoxicity ( J:91396 )

• kainate causes enhanced excitotoxicity induced neuronal cell death in mutants compared to wild-type mice

Genotype
MGI:4417864

cx4

• Allelic Composition: Hyou1^tm1Oga/Hyou1⁺; Sil1^{Gt(RST462)Byg}/Sil1^{Gt(RST462)Byg}
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J

nervous system

abnormal Purkinje cell morphology ( J:154993 )

• at 6 to 8 weeks, Purkinje cells accumulate ubiquitin+ inclusions, a marker of endoplasmic reticulum stress

Purkinje cell degeneration ( J:154993 )

• at 4 and 6 weeks, Purkinje cells exhibit degeneration

• by 20 weeks most Purkinje cells have degenerated

• unlike Sil1^{Gt(RST462)Byg} homozygotes, Purkinje cells in lobule X and caudal lobule IX degenerate by 3 months of age

behavior/neurological

ataxia ( J:154993 )

• beginning at 2 months and extreme by 20 weeks

abnormal posture ( J:154993 )

• at 10 weeks, mice exhibit a wide stance compared with wild-type mice