All Phenotypes Tg(Mpz-cre)2Brn MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nf2^tm2Gth/Nf2^tm2Gth Trp53^tm1Brd/Trp53⁺ Tg(Mpz-cre)2Brn/0	involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N	MGI:3850407
cn2	Nf2^tm2Gth/Nf2^tm2Gth Trp53^tm1Brd/Trp53^tm1Brd Tg(Mpz-cre)2Brn/0	involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N	MGI:3850408
cn3	Nf2^tm2Gth/Nf2^tm2Gth Tg(Mpz-cre)2Brn/0	involves: 129P2/OlaHsd * FVB/N	MGI:3850389
cn4	Nf2^tm1Gth/Nf2^tm2Gth Tg(Mpz-cre)2Brn/0	involves: 129P2/OlaHsd * FVB/N	MGI:3850394

Allelic Composition	Nf2^tm2Gth/Nf2^tm2Gth Trp53^tm1Brd/Trp53⁺ Tg(Mpz-cre)2Brn/0
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2^tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Tg(Mpz-cre)2Brn mutation (1 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:92413 )

premature death ( J:92413 )

• median age of death is 4.5 months

neoplasm

osseous metaplasia ( J:92413 )

• 23% of mice develop osseous metaplasia

increased sarcoma incidence ( J:92413 )

• one mouse developed lymphosarcoma

increased leiomyosarcoma incidence ( J:92413 )

• in 8% of mice with metastasis to the liver

increased nervous system tumor incidence ( J:92413 )

• 85% of mice develop peripheral nerve tumors

increased neurofibroma incidence ( J:92413 )

• 8% of mice develop neurofibroma

increased neurofibrosarcoma incidence ( J:92413 )

• 77% of mice develop peripheral nerve tumors from peripheral nerves of the limbs and from the dorsal root ganglia

increased Schwannoma incidence ( J:92413 )

• 11% of mice develop schwannoma

skeleton

abnormal tooth development ( J:92413 )

• 35% of mice exhibit odontoblastic hyperplasia

abnormal osteoblast morphology ( J:92413 )

• 15% of mice develop osteogenic hyperplasia

nervous system

increased nervous system tumor incidence ( J:92413 )

• 85% of mice develop peripheral nerve tumors

increased neurofibroma incidence ( J:92413 )

• 8% of mice develop neurofibroma

increased neurofibrosarcoma incidence ( J:92413 )

• 77% of mice develop peripheral nerve tumors from peripheral nerves of the limbs and from the dorsal root ganglia

increased Schwannoma incidence ( J:92413 )

• 11% of mice develop schwannoma

abnormal Schwann cell morphology ( J:92413 )

• 81% of mice exhibit Schwann cell hyperplasia with increased incidence of diffuse Schwann cell hyperplasia in major peripheral nerve trunks

renal/urinary system

abnormal renal tubule morphology ( J:92413 )

• 73% of mice exhibit renal tubular cell hyperplasia

vision/eye

cataract ( J:92413 )

• 85% of mice

craniofacial

abnormal tooth development ( J:92413 )

• 35% of mice exhibit odontoblastic hyperplasia

growth/size/body

abnormal tooth development ( J:92413 )

• 35% of mice exhibit odontoblastic hyperplasia

muscle

increased leiomyosarcoma incidence ( J:92413 )

• in 8% of mice with metastasis to the liver

Allelic Composition	Nf2^tm2Gth/Nf2^tm2Gth Trp53^tm1Brd/Trp53^tm1Brd Tg(Mpz-cre)2Brn/0
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:92413 )

• mice die a few months of birth

neoplasm

osseous metaplasia ( J:92413 )

• 38% of mice develop osseous metaplasia

increased tumor incidence ( J:92413 )

increased sarcoma incidence ( J:92413 )

• at 2 to 3.5 months, 25% of mice develop 4 sarcoma mainly in the ganglia

increased rhabdomyosarcoma incidence ( J:92413 )

• in one mouse

increased neurofibrosarcoma incidence ( J:92413 )

• at 2 to 3.5 months, 50% of mice develop 4 malignant peripheral nerve sheath tumors

increased extremity angiosarcoma incidence ( J:92413 )

• in 63% of mice

increased osteosarcoma incidence ( J:92413 )

• in one mouse

increased osteoma incidence ( J:92413 )

• one mouse developed osteomas

skeleton

increased osteosarcoma incidence ( J:92413 )

• in one mouse

increased osteoma incidence ( J:92413 )

• one mouse developed osteomas

abnormal osteoblast morphology ( J:92413 )

• 25% of mice develop osteogenic hyperplasia

nervous system

increased neurofibrosarcoma incidence ( J:92413 )

• at 2 to 3.5 months, 50% of mice develop 4 malignant peripheral nerve sheath tumors

abnormal Schwann cell morphology ( J:92413 )

• 38% of mice exhibit Schwann cell hyperplasia

renal/urinary system

abnormal renal tubule morphology ( J:92413 )

• 63% of mice exhibit renal tubular cell hyperplasia

vision/eye

cataract ( J:92413 )

• 75% of mice

muscle

increased rhabdomyosarcoma incidence ( J:92413 )

• in one mouse

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:63264 )

premature death ( J:63264 )

• few mice survive beyond 24 months of age

postnatal lethality, incomplete penetrance ( J:63264 )

• fewer mice than expected are obtained (no time point for lethality given)

growth/size/body

abnormal tooth development ( J:92413 )

• one mouse exhibited odontoblastic hyperplasia

decreased body size ( J:63264 )

• although not as much as in Tg(P0-Cre)1Gth conditional knock-outs of Nf2

decreased body weight ( J:63264 )

• although not as much as in Tg(P0-Cre)1Gth conditional knock-outs of Nf2

nervous system

increased neurofibrosarcoma incidence ( J:92413 )

• 1 of 27 mice develop peripheral nerve tumors

increased Schwannoma incidence ( J:63264 , J:92413 )

• 4% of mice develop schwannomas (J:63264)

abnormal Schwann cell morphology ( J:63264 , J:92413 )

• mice exhibit Schwann cell hyperplasia (J:63264)

• occasionally whorls of thin cytoplasmic processes are observed in Schwann cells (J:63264)

• 100% of mice exhibit Schwann cell hyperplasia (J:92413)

neoplasm

osseous metaplasia ( J:92413 )

• 25% of mice develop osseous metaplasia

increased lung adenocarcinoma incidence ( J:92413 )

• in one mouse

increased renal carcinoma incidence ( J:92413 )

• 25% of mice develop carcinoma in situ in the kidney

increased neurofibrosarcoma incidence ( J:92413 )

• 1 of 27 mice develop peripheral nerve tumors

increased extremity angiosarcoma incidence ( J:92413 )

• in one mouse

increased Schwannoma incidence ( J:63264 , J:92413 )

• 4% of mice develop schwannomas (J:63264)

skeleton

abnormal tooth development ( J:92413 )

• one mouse exhibited odontoblastic hyperplasia

abnormal osteoblast morphology ( J:92413 )

• 25% of mice develop osteogenic hyperplasia

renal/urinary system

increased renal carcinoma incidence ( J:92413 )

• 25% of mice develop carcinoma in situ in the kidney

abnormal renal tubule morphology ( J:92413 )

• 25% of mice develop carcinoma in situ in the kidney

vision/eye

cataract ( J:63264 , J:92413 )

• in 59% of mice, in which 50% of cases are bilateral (J:63264)

• 86% of mice (J:92413)

hearing/vestibular/ear

increased susceptibility to otitis media ( J:63264 )

immune system

increased susceptibility to otitis media ( J:63264 )

craniofacial

abnormal tooth development ( J:92413 )

• one mouse exhibited odontoblastic hyperplasia

respiratory system

increased lung adenocarcinoma incidence ( J:92413 )

• in one mouse

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:63264

Allelic Composition	Nf2^tm1Gth/Nf2^tm2Gth Tg(Mpz-cre)2Brn/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2^tm1Gth mutation (1 available); any Nf2 mutation (65 available)
Nf2^tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Tg(Mpz-cre)2Brn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:63264 )

premature death ( J:63264 )

• 50% of mice die within the first year

craniofacial

delayed tooth eruption ( J:63264 )

• retarded or absent

failure of tooth eruption ( J:63264 )

• retarded or absent

growth/size/body

delayed tooth eruption ( J:63264 )

• retarded or absent

failure of tooth eruption ( J:63264 )

• retarded or absent

decreased body size ( J:63264 )

decreased body weight ( J:63264 )

hearing/vestibular/ear

increased susceptibility to otitis media ( J:63264 )

immune system

increased susceptibility to otitis media ( J:63264 )

skeleton

delayed tooth eruption ( J:63264 )

• retarded or absent

failure of tooth eruption ( J:63264 )

• retarded or absent

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:63264

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24