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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mybtm1Cgn
targeted mutation 1, University of Cologne
MGI:3047075
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Mybtm1Cgn/Mybtm1.1Cgn involves: 129P2/OlaHsd * C57BL/6 MGI:3047330
cn2
 		Mybtm1Cgn/Mybtm1.1Cgn
Tg(Lck-cre)548Jxm/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3047331
cn3
 		Mybtm1Cgn/Mybtm1Cgn
Tg(Lck-cre)548Jxm/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3047332
cn4
 		Mybtm1Cgn/Mybtm1Cgn
Tg(Lck-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3047333


Genotype
MGI:3047330
ht1
Allelic
Composition		 Mybtm1Cgn/Mybtm1.1Cgn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybtm1.1Cgn mutation (0 available); any Myb mutation (53 available)
Mybtm1Cgn mutation (1 available); any Myb mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:91122 )
• compound heterozygotes are healthy and fertile




Genotype
MGI:3047331
cn2
Allelic
Composition		 Mybtm1Cgn/Mybtm1.1Cgn
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybtm1.1Cgn mutation (0 available); any Myb mutation (53 available)
Mybtm1Cgn mutation (1 available); any Myb mutation (53 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced
decreased double-positive T cell number ( J:91122 )
• the absolute number of double positive cells is decreased
decreased CD4-positive, alpha-beta T cell number ( J:91122 )
• the absolute number of CD4 single positive cells is decreased

immune system
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced
decreased double-positive T cell number ( J:91122 )
• the absolute number of double positive cells is decreased
decreased CD4-positive, alpha-beta T cell number ( J:91122 )
• the absolute number of CD4 single positive cells is decreased

endocrine/exocrine glands
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced




Genotype
MGI:3047332
cn3
Allelic
Composition		 Mybtm1Cgn/Mybtm1Cgn
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybtm1Cgn mutation (1 available); any Myb mutation (53 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced about 75%
decreased double-positive T cell number ( J:91122 )
• the absolute number of double positive cells is decreased about 80%
decreased CD4-positive, alpha-beta T cell number ( J:91122 )
• the absolute number of CD4 single positive cells is decreased about 80%

immune system
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced about 75%
decreased double-positive T cell number ( J:91122 )
• the absolute number of double positive cells is decreased about 80%
decreased CD4-positive, alpha-beta T cell number ( J:91122 )
• the absolute number of CD4 single positive cells is decreased about 80%

endocrine/exocrine glands
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced about 75%




Genotype
MGI:3047333
cn4
Allelic
Composition		 Mybtm1Cgn/Mybtm1Cgn
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybtm1Cgn mutation (1 available); any Myb mutation (53 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced about 97%
decreased double-negative T cell number ( J:91122 )
• the absolute number of double negative cells is decreased about 40% however the proportion of double negative cells is increased to about 60% of total thymocytes
• about 90% of the double negative cells are CD44-CD25+ DN3 cells
decreased double-positive T cell number ( J:91122 )
• the absolute number of double positive cells is greatly decreased
arrested T cell differentiation ( J:91122 )
• a block in thymocyte maturation at the DN3 stage or in the transition from DN3 to DN4 appears to occur
decreased CD4-positive, alpha-beta T cell number ( J:91122 )
• the absolute number of CD4 single positive cells is greatly decreased
decreased CD8-positive, alpha-beta T cell number ( J:91122 )
• the absolute number of CD8 single positive cells is greatly decreased
decreased gamma-delta T cell number ( J:91122 )
• the number of gamma delta TCR bearing thymocytes is decreased

immune system
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced about 97%
decreased double-negative T cell number ( J:91122 )
• the absolute number of double negative cells is decreased about 40% however the proportion of double negative cells is increased to about 60% of total thymocytes
• about 90% of the double negative cells are CD44-CD25+ DN3 cells
decreased double-positive T cell number ( J:91122 )
• the absolute number of double positive cells is greatly decreased
arrested T cell differentiation ( J:91122 )
• a block in thymocyte maturation at the DN3 stage or in the transition from DN3 to DN4 appears to occur
decreased CD4-positive, alpha-beta T cell number ( J:91122 )
• the absolute number of CD4 single positive cells is greatly decreased
decreased CD8-positive, alpha-beta T cell number ( J:91122 )
• the absolute number of CD8 single positive cells is greatly decreased
decreased gamma-delta T cell number ( J:91122 )
• the number of gamma delta TCR bearing thymocytes is decreased

endocrine/exocrine glands
thymus hypoplasia ( J:91122 )
• thymus cellularity is reduced about 97%




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory