Phenotypes associated with this allele

• Allele Symbol: Myb^tm1.1Cgn
• Allele Name: targeted mutation 1.1, University of Cologne
• Allele ID: MGI:3047076
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myb^tm1.1Cgn/Myb^tm1.1Cgn	involves: 129P2/OlaHsd * C57BL/6	MGI:3047329
ht2	Myb^tm1.1Cgn/Myb^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3764008
ht3	Myb^tm1Cgn/Myb^tm1.1Cgn	involves: 129P2/OlaHsd * C57BL/6	MGI:3047330
cn4	Myb^tm1Cgn/Myb^tm1.1Cgn Tg(Lck-cre)548Jxm/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3047331

Genotype
MGI:3047329

hm1

• Allelic Composition: Myb^tm1.1Cgn/Myb^tm1.1Cgn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:91122 )

• homozygous embryos die between E14 - E15

hematopoietic system

anemia ( J:91122 )

• embryos die with extreme anemia between E14 - E15

Genotype
MGI:3764008

ht2

• Allelic Composition: Myb^tm1.1Cgn/Myb⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

hematopoietic system

arrested B cell differentiation ( J:127234 )

• block at pro- to pre-B cell transition is seen in young mice

decreased mature B cell number ( J:127234 )

• reduced in spleen at younger ages

decreased B-1 B cell number ( J:127234 )

• numbers are decreased in spleen and peritoneal cavity at 10-16 weeks of age

decreased pre-B cell number ( J:127234 )

• numbers are reduced in bone marrow and persists over time

immune system

arrested B cell differentiation ( J:127234 )

• block at pro- to pre-B cell transition is seen in young mice

decreased mature B cell number ( J:127234 )

• reduced in spleen at younger ages

decreased B-1 B cell number ( J:127234 )

• numbers are decreased in spleen and peritoneal cavity at 10-16 weeks of age

decreased pre-B cell number ( J:127234 )

• numbers are reduced in bone marrow and persists over time

Genotype
MGI:3047330

ht3

• Allelic Composition: Myb^tm1Cgn/Myb^tm1.1Cgn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:91122 )

• compound heterozygotes are healthy and fertile

Genotype
MGI:3047331

cn4

• Allelic Composition: Myb^tm1Cgn/Myb^tm1.1Cgn; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

hematopoietic system

thymus hypoplasia ( J:91122 )

• thymus cellularity is reduced

decreased double-positive T cell number ( J:91122 )

• the absolute number of double positive cells is decreased

decreased CD4-positive, alpha-beta T cell number ( J:91122 )

• the absolute number of CD4 single positive cells is decreased

immune system

thymus hypoplasia ( J:91122 )

• thymus cellularity is reduced

decreased double-positive T cell number ( J:91122 )

• the absolute number of double positive cells is decreased

decreased CD4-positive, alpha-beta T cell number ( J:91122 )

• the absolute number of CD4 single positive cells is decreased

endocrine/exocrine glands

thymus hypoplasia ( J:91122 )

• thymus cellularity is reduced