Phenotypes associated with this allele

• Allele Symbol: Tg(TTR-V30M)15Imeg
• Allele Name: transgene insertion 15, Institute of Molecular Embryology and Genetics
• Allele ID: MGI:3047080
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hsf1^tm1Ijb/Hsf1^tm1Ijb Tg(TTR-V30M)15Imeg/0	involves: 129S6/SvEvTac * BALB/c * C57BL/6	MGI:4429562
cx2	Tg(TTR-V30M)15Imeg/0 Ttr^tm1Wsb/Ttr^tm1Wsb	involves: 129S/SvEv * C57BL/6	MGI:6196488
tg3	Tg(TTR-V30M)15Imeg/0	involves: C57BL/6	MGI:6196487
tg4	Tg(TTR-V30M)15Imeg/0	Not Specified	MGI:3613376

Genotype
MGI:4429562

cx1

• Allelic Composition: Hsf1^tm1Ijb/Hsf1^tm1Ijb; Tg(TTR-V30M)15Imeg/0
• Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:156658 )

N • as in human patients with familial amyloidotic polyneuropathy, no transthyretin deposition is observed in the brain and spinal cord

abnormal axon morphology ( J:156658 )

• after 24 months, mice exhibit a decrease in the number of unmyelinated fibers and myelinated fibers in sciatic nerves with transthyretin depositions unlike in wild-type mice

abnormal dorsal root ganglion morphology ( J:156658 )

• at 3 months, some mice exhibit transthyretin depositions in the dorsal root ganglion unlike wild-type or Tg(TTR-V30M)15Imeg mice

• penetrance of thranthyretin increases with age

abnormal sciatic nerve morphology ( J:156658 )

• mice exhibit transthyretin depositions in the sciatic nerve unlike wild-type or Tg(TTR-V30M)15Imeg mice

neurodegeneration ( J:156658 )

• at 24 months, mice exhibit collagen pockets indicating neurodegeneration unlike in Tg(TTR-V30M)15Imeg mice

digestive/alimentary system

abnormal digestive system morphology ( J:156658 )

• from 1 to 24 months of age, mice exhibit transthyretin depositions in the gastrointestinal tract unlike in wild-type mice

• mice exhibit a 2- to 3-fold higher penetrance of transthyretin deposition compared with Tg(TTR-V30M)15Imeg mice

abnormal stomach morphology ( J:156658 )

• at 6 months, mice exhibit amyloid depositions in the stomach unlike wild-type mice

• a higher number of older mice exhibit amyloid depositions in the stomach

immune system

increased interleukin-1 beta secretion ( J:156658 )

• in sciatic nerves and neurons of ganglion that exhibit transthyretin deposition

increased tumor necrosis factor secretion ( J:156658 )

• in sciatic nerves and neurons of ganglion that exhibit transthyretin deposition

integument

abnormal skin morphology ( J:156658 )

• at 3 months, mice exhibit transthyretin depositions in the skin unlike wild-type or Tg(TTR-V30M)15Imeg mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
transthyretin amyloidosis		DOID:0050638	OMIM:105210	J:156658

Genotype
MGI:6196488

cx2

• Allelic Composition: Tg(TTR-V30M)15Imeg/0; Ttr^tm1Wsb/Ttr^tm1Wsb
• Genetic Background: involves: 129S/SvEv * C57BL/6

homeostasis/metabolism

amyloidosis ( J:260683 )

• amyloid deposition is seen only in the intestinal tract, first found in the alimentary tract at 12 months of age

cardiovascular system

abnormal heart morphology ( J:260683 )

• 10-30% of mice show TTR+ deposits in the heart and kidneys at 12 months of age, 30-50% of mice at 18 months of age, and 30-100% of mice at 24 months of age

digestive/alimentary system

abnormal small intestine morphology ( J:260683 )

• anti-human TTR+ deposits are seen in all mice in the small intestine at 12 months of age

renal/urinary system

abnormal kidney morphology ( J:260683 )

• 10-30% of mice show TTR+ deposits in the heart and kidneys at 12 months of age, 30-50% of mice at 18 months of age, and 30-100% of mice at 24 months of age

Genotype
MGI:6196487

tg3

• Allelic Composition: Tg(TTR-V30M)15Imeg/0
• Genetic Background: involves: C57BL/6

homeostasis/metabolism

amyloidosis ( J:260683 )

• amyloid deposition is seen only in the intestinal tract, first found in the alimentary tract at 12 months of age

cardiovascular system

abnormal heart morphology ( J:260683 )

• 10-30% of mice show TTR+ deposits in the heart and kidneys at 12 months of age, 30-50% of mice at 18 months of age, and 30-100% of mice at 24 months of age

digestive/alimentary system

abnormal small intestine morphology ( J:260683 )

• anti-human TTR+ deposits are seen in all mice in the small intestine at 12 months of age

renal/urinary system

abnormal kidney morphology ( J:260683 )

• 10-30% of mice show TTR+ deposits in the heart and kidneys at 12 months of age, 30-50% of mice at 18 months of age, and 30-100% of mice at 24 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
transthyretin amyloidosis		DOID:0050638	OMIM:105210	J:260683

Genotype
MGI:3613376

tg4

• Allelic Composition: Tg(TTR-V30M)15Imeg/0
• Genetic Background: Not Specified

homeostasis/metabolism

amyloidosis ( J:80880 )

• amyloid deposition starts in the gastrointestinal tract, cardiovascular system, and kidneys 6 months after birth and extends to various other organs and tissues with advancing age

• however, amyloid does not accumulate in the choroid plexus and in the peripheral and autonomic nervous systems

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
transthyretin amyloidosis		DOID:0050638	OMIM:105210	J:80880