All Phenotypes Aplnr<tm1Afu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Aplnr^tm1Afu
targeted mutation 1, Akiyoshi Fukamizu
MGI:3047284

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aplnr^tm1Afu/Aplnr^tm1Afu	involves: C57BL/6 * CBA	MGI:3047398

Allelic Composition	Aplnr^tm1Afu/Aplnr^tm1Afu
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplnr^tm1Afu mutation (0 available); any Aplnr mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:91164 )

N	• base-line systolic blood pressure and heart rate are normal • histology of the heart and other organs is normal

abnormal systemic arterial blood pressure ( J:91164 )

• responsiveness to exogenous angiotensin II is increased when endogenous angiotensin II production has been inhibited in homozygotes compared to wild-type mice under the same conditions

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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