Phenotypes associated with this allele

• Allele Symbol: Tnfsf13b^tm1Cleg
• Allele Name: targeted mutation 1, Chris H Clegg
• Allele ID: MGI:3047300
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfsf13b^tm1Cleg/Tnfsf13b^tm1Cleg	involves: 129S5/SvEvBrd	MGI:3718449

Genotype
MGI:3718449

hm1

• Allelic Composition: Tnfsf13b^tm1Cleg/Tnfsf13b^tm1Cleg
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte morphology ( J:71301 )

abnormal B cell differentiation ( J:71301 )

• B cell development is blocked at the transitional T1 stage such that virtually no T2, marginal zone or follicular B cells are detected

decreased mature B cell number ( J:71301 )

• mature circulating B cells are reduced

decreased follicular B cell number ( J:71301 )

decreased memory T cell number ( J:71301 )

• memory/effector T cells are reduced in number (6.6+/-2.2(x10^-8) compared to 13.6+/-5.6(x10^-8) in wild-type mice)

increased T cell number ( J:71301 )

• CD3+ T cell numbers are increased

abnormal B cell physiology ( J:71301 )

decreased IgG level ( J:71301 )

• IgG levels are decreased by 4.6-fold

decreased IgM level ( J:71301 )

• IgM levels are decreased by 3.9-fold

abnormal lymph organ size ( J:71301 )

spleen hypoplasia ( J:71301 )

• spleen cellularity is reduced

lymph node hypoplasia ( J:71301 )

• lymph nodes have reduced numbers of cells

hematopoietic system

abnormal leukocyte morphology ( J:71301 )

abnormal B cell differentiation ( J:71301 )

• B cell development is blocked at the transitional T1 stage such that virtually no T2, marginal zone or follicular B cells are detected

decreased mature B cell number ( J:71301 )

• mature circulating B cells are reduced

decreased follicular B cell number ( J:71301 )

decreased memory T cell number ( J:71301 )

• memory/effector T cells are reduced in number (6.6+/-2.2(x10^-8) compared to 13.6+/-5.6(x10^-8) in wild-type mice)

increased T cell number ( J:71301 )

• CD3+ T cell numbers are increased

spleen hypoplasia ( J:71301 )

• spleen cellularity is reduced

abnormal B cell physiology ( J:71301 )

decreased IgG level ( J:71301 )

• IgG levels are decreased by 4.6-fold

decreased IgM level ( J:71301 )

• IgM levels are decreased by 3.9-fold