Phenotypes associated with this allele

• Allele Symbol: Abcc4^tm1Jsch
• Allele Name: targeted mutation 1, John D Schuetz
• Allele ID: MGI:3047326
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcc4^tm1Jsch/Abcc4^tm1Jsch	involves: 129X1/SvJ	MGI:3055390

Genotype
MGI:3055390

hm1

• Allelic Composition: Abcc4^tm1Jsch/Abcc4^tm1Jsch
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood-brain barrier function ( J:92788 )

• whole brain concentrations of topotecan, an organic anion, are increased almost 6-fold as a result of decreased anion transporter activity

abnormal blood-cerebrospinal fluid barrier function ( J:92788 )

• cerebrospinal fluid concentrations of topotecan, an organic anion, are increased almost 10-fold as a result of decreased anion transporter activity

renal/urinary system

abnormal urine organic anion level ( J:92788 )

• plasma concentrations is increased and urinary concentration of totpotecan is decreased indicating decreased renal excretion

nervous system

abnormal blood-brain barrier function ( J:92788 )

• whole brain concentrations of topotecan, an organic anion, are increased almost 6-fold as a result of decreased anion transporter activity

abnormal blood-cerebrospinal fluid barrier function ( J:92788 )

• cerebrospinal fluid concentrations of topotecan, an organic anion, are increased almost 10-fold as a result of decreased anion transporter activity

homeostasis/metabolism

abnormal urine organic anion level ( J:92788 )

• plasma concentrations is increased and urinary concentration of totpotecan is decreased indicating decreased renal excretion