All Phenotypes Pbx2<tm1Mlc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pbx2^tm1Mlc
targeted mutation 1, Michael L Cleary
MGI:3047327

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pbx2^tm1Mlc/Pbx2^tm1Mlc	either: 129S/Sv or (involves: 129S/Sv * C57BL/6)	MGI:3047356
cn2	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd * 129S/Sv	MGI:5305855
cn3	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Tg(Tcfap2a-cre)1Will/0	involves: 129P2/OlaHsd * 129S/Sv	MGI:5305925
cn4	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2^tm1Mlc Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd * 129S/Sv	MGI:5305923
cn5	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Nkx2-5^tm2(cre)Rph/Nkx2-5⁺	involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv	MGI:5426982
cn6	Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}/Gt(ROSA)26Sor⁺ Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Tg(Tcfap2a-cre)1Will/0	involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ	MGI:5305934
cn7	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA/J	MGI:5305927
cx8	Pbx1^tm1Mlc/Pbx1⁺ Pbx2^tm1Mlc/Pbx2⁺ Pbx3^tm1Mlc/Pbx3⁺	involves: 129S6/SvEvTac	MGI:5305931
cx9	Pbx1^tm1Mlc/Pbx1^tm1Mlc Pbx2^tm1Mlc/Pbx2⁺	involves: 129S6/SvEvTac	MGI:5305928

Allelic Composition	Pbx2^tm1Mlc/Pbx2^tm1Mlc
Genetic Background	either: 129S/Sv or (involves: 129S/Sv * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx2^tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:91079 )

N	• no difference in hemoglobin content, erythrocyte indices, or leukocyte or platelet counts are detected

immune system

immune system phenotype ( J:91079 )

N	• no difference in absolute or relative B or T cell numbers is detected

skeleton

skeleton phenotype ( J:91079 )

N	• no defect in skeletal or cartilaginous development is detected

normal phenotype

no abnormal phenotype detected ( J:91079 )

• homozygotes are viable with normal body and organ weights, fertility, and longevity

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2^tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:178316 )

craniofacial

abnormal maxillary shelf morphology ( J:178316 )

• abnormal maxillary palatal and palatine process

absent premaxilla ( J:178316 )

• the premaxillary process is absent

abnormal nasal capsule morphology ( J:178316 )

bilateral cleft upper lip ( J:178316 )

• bilateral cleft lip

cleft palate ( J:178316 )

respiratory system

abnormal nasal capsule morphology ( J:178316 )

digestive/alimentary system

abnormal maxillary shelf morphology ( J:178316 )

• abnormal maxillary palatal and palatine process

cleft palate ( J:178316 )

skeleton

abnormal maxillary shelf morphology ( J:178316 )

• abnormal maxillary palatal and palatine process

absent premaxilla ( J:178316 )

• the premaxillary process is absent

abnormal nasal capsule morphology ( J:178316 )

growth/size/body

abnormal maxillary shelf morphology ( J:178316 )

• abnormal maxillary palatal and palatine process

abnormal nasal capsule morphology ( J:178316 )

bilateral cleft upper lip ( J:178316 )

• bilateral cleft lip

cleft palate ( J:178316 )

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Tg(Tcfap2a-cre)1Will/0
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2^tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)
Tg(Tcfap2a-cre)1Will mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

cleft upper lip ( J:178316 )

• cleft lip and/or palate

cleft palate ( J:178316 )

• cleft lip and/or palate

digestive/alimentary system

cleft palate ( J:178316 )

• cleft lip and/or palate

growth/size/body

cleft upper lip ( J:178316 )

• cleft lip and/or palate

cleft palate ( J:178316 )

• cleft lip and/or palate

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2^tm1Mlc Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

bilateral cleft upper lip ( J:178316 )

• bilateral cleft lip

cellular

decreased apoptosis ( J:178316 )

• in the nasal epithelial at E10.75

growth/size/body

bilateral cleft upper lip ( J:178316 )

• bilateral cleft lip

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Nkx2-5^tm2(cre)Rph/Nkx2-5⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5^tm2(cre)Rph mutation (1 available); any Nkx2-5 mutation (21 available)
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2^tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal spleen morphology ( J:184521 )

• hypoplastic and fragmented

• more severe than in mutant mice wild-type for Pbx2

spleen hypoplasia ( J:184521 )

immune system

abnormal spleen morphology ( J:184521 )

• hypoplastic and fragmented

• more severe than in mutant mice wild-type for Pbx2

spleen hypoplasia ( J:184521 )

Allelic Composition	Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc}/Gt(ROSA)26Sor⁺ Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ Tg(Tcfap2a-cre)1Will/0
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Wnt1/GFP)Amc} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2^tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)
Tg(Tcfap2a-cre)1Will mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:178316 )

N	• the cleft lip phenotype observed in Pbx1^tm1.1Koss/Pbx1^tm1.1Koss Pbx2^tm1Mlc/Pbx2⁺ Tg(Tcfap2a*-cre)1Will is rescued

Allelic Composition	Pbx1^tm1Koss/Pbx1^tm1Koss Pbx2^tm1Mlc/Pbx2⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Pbx1^tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2^tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:178316 )

craniofacial

cleft palate ( J:178316 )

nervous system

nervous system phenotype ( J:178316 )

N	• cranial neural crest cell migration and olfactory placodes are normal

digestive/alimentary system

cleft palate ( J:178316 )

growth/size/body

cleft palate ( J:178316 )

Allelic Composition	Pbx1^tm1Mlc/Pbx1⁺ Pbx2^tm1Mlc/Pbx2⁺ Pbx3^tm1Mlc/Pbx3⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pbx1^tm1Mlc mutation (0 available); any Pbx1 mutation (40 available)
Pbx2^tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)
Pbx3^tm1Mlc mutation (0 available); any Pbx3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

cleft palate ( J:178316 )

digestive/alimentary system

cleft palate ( J:178316 )

mortality/aging

neonatal lethality, complete penetrance ( J:178316 )

growth/size/body

cleft palate ( J:178316 )

Allelic Composition	Pbx1^tm1Mlc/Pbx1^tm1Mlc Pbx2^tm1Mlc/Pbx2⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

micrognathia ( J:178316 )

• bilateral or unilateral

abnormal lateral nasal prominence morphology ( J:178316 )

• abnormally fused at E11.5 with persistence of an abnormal bridge connecting their posterior aspects to the anterior maxillary process

abnormal maxillary prominence morphology ( J:178316 )

• abnormally fused at E11.5 with persistence of an abnormal bridge connecting their posterior aspects to the anterior maxillary process

abnormal medial nasal prominence morphology ( J:178316 )

• abnormally fused at E11.5 with persistence of an abnormal bridge connecting their posterior aspects to the anterior maxillary process

cleft upper lip ( J:178316 )

bilateral cleft upper lip ( J:178316 )

• bilateral or unilateral cleft lip and/or palate

unilateral cleft upper lip ( J:178316 )

• bilateral or unilateral cleft lip and/or palate

tongue hypoplasia ( J:178316 )

small snout ( J:178316 )

• small nose

homeostasis/metabolism

edema ( J:178316 )

• head edema with E13.5

skeleton

micrognathia ( J:178316 )

• bilateral or unilateral

digestive/alimentary system

tongue hypoplasia ( J:178316 )

growth/size/body

cleft upper lip ( J:178316 )

bilateral cleft upper lip ( J:178316 )

• bilateral or unilateral cleft lip and/or palate

unilateral cleft upper lip ( J:178316 )

• bilateral or unilateral cleft lip and/or palate

tongue hypoplasia ( J:178316 )

small snout ( J:178316 )

• small nose

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