Phenotypes associated with this allele

• Allele Symbol: Myl2^{tm1(Hand1)Tana}
• Allele Name: targeted mutation 1, Makoto Tanaka
• Allele ID: MGI:3047382
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Myl2^tm1(Hand1)Tana/Myl2^+	involves: 129X1/SvJ * C57BL/6J	MGI:3047716

Genotype
MGI:3047716

ht1

• Allelic Composition: Myl2^{tm1(Hand1)Tana}/Myl2⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:91082 )

• mutants die between E12.5 and E14.5 (no live embryos recovered)

cardiovascular system

thin myocardium compact layer ( J:91082 )

• at E11.5 the compact zone myocardium is thinner

abnormal heart development ( J:91082 )

• at E9.5 the interventricular groove is absent

• at E10.5 a single ventricular chamber lacking the interventricular groove and interventricular septum is seen along with increased expansion of the ventricle especially on the right side compared to wild-type

• at E11.5 the interventricular groove and interventricular septum are still absent and the compact zone myocardium is thinner

common ventricle ( J:91082 )

• at E10.5 a single ventricular chamber lacking the interventricular groove and interventricular septum is seen

• at E11.5 the interventricular septum is still absent

abnormal interventricular groove morphology ( J:91082 )

• from E9.5 to E11.5, the interventricular groove is absent

growth/size/body

embryonic growth retardation ( J:91082 )

• embryos become slightly growth retarded by E11.5 and severely growth retarded by E12.5

embryo

embryonic growth retardation ( J:91082 )

• embryos become slightly growth retarded by E11.5 and severely growth retarded by E12.5

muscle

thin myocardium compact layer ( J:91082 )

• at E11.5 the compact zone myocardium is thinner