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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(KRT14-HPV16)wt1Dh
transgene insertion wt1, Douglas Hanahan
MGI:3047406
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Mmp9tm1Tvu/Mmp9tm1Tvu
Tg(KRT14-HPV16)wt1Dh/0 		involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * FVB/N MGI:4367274
tg2
 		Tg(KRT14-HPV16)wt1Dh/0 C.Cg-Tg(KRT14-HPV16)wt1Dh MGI:4849991
tg3
 		Tg(KRT14-HPV16)wt1Dh/0 either: FVB.Cg-Tg(KRT14-HPV16)wt1Dh or (involves: C57BL/6 * DBA/2 * FVB/N) MGI:4849989
tg4
 		Tg(KRT14-HPV16)wt1Dh/0 either: (involves: C57BL/6 * DBA/2) or (involves: C57BL/6 * DBA/2 * SENCAR * SSIN) MGI:4849990
tg5
 		Tg(KRT14-HPV16)wt1Dh/0 FVB.Cg-Tg(KRT14-HPV16)wt1Dh/Nci MGI:4367275


Genotype
MGI:4367274
cx1
Allelic
Composition		 Mmp9tm1Tvu/Mmp9tm1Tvu
Tg(KRT14-HPV16)wt1Dh/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp9tm1Tvu mutation (2 available); any Mmp9 mutation (50 available)
Tg(KRT14-HPV16)wt1Dh mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin squamous cell carcinoma incidence ( J:65699 )
• 27% of mice develop squamous cell carcinomas (SCCs) in the epidermis with more malignancy (increased aggressiveness and higher grade) compared to in Tg(KRT14-HPV16)wt1Dh mice
decreased tumor incidence ( J:65699 )
• mice exhibit fewer incidence of malignant conversions compared with Tg(KRT14-HPV16)wt1Dh mice
• 27% of mice develop squamous cell carcinomas (SCCs) in the epidermis compared to 50% of Tg(KRT14-HPV16)wt1Dh mice
• however, the numbers of SCCs per mouse is the same as in Tg(KRT14-HPV16)wt1Dh mice, and expression of the wild-type allele restores normal Tg(KRT14-HPV16)wt1Dh-induced neoplasia

integument
decreased keratinocyte proliferation ( J:65699 )
• compared to in Tg(KRT14-HPV16)wt1Dh mice
abnormal epidermal layer morphology ( J:65699 )
• at 2 months, all mice exhibit mild hyperplastic epidermis compared to in wild-type mice but not as severe as in Tg(KRT14-HPV16)wt1Dh mice
• at 4 months, 20% of mice develop epidermal dysplasia unlike in wild-type mice
• at 7 months, 90% of mice exhibit epidermal dysplasia unlike in wild-type mice
increased skin squamous cell carcinoma incidence ( J:65699 )
• 27% of mice develop squamous cell carcinomas (SCCs) in the epidermis with more malignancy (increased aggressiveness and higher grade) compared to in Tg(KRT14-HPV16)wt1Dh mice

cellular
decreased keratinocyte proliferation ( J:65699 )
• compared to in Tg(KRT14-HPV16)wt1Dh mice




Genotype
MGI:4849991
tg2
Allelic
Composition		 Tg(KRT14-HPV16)wt1Dh/0
Genetic
Background		 C.Cg-Tg(KRT14-HPV16)wt1Dh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-HPV16)wt1Dh mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:20130 )
N
• Background Sensitivity: mice do not exhibit malignant carcinoma unlike mice on a background containing FVB/N

integument
abnormal skin morphology ( J:20130 )
• mice exhibit skin dysplasia compared with wild-type mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT skin squamous cell carcinoma DOID:3151 J:20130




Genotype
MGI:4849989
tg3
Allelic
Composition		 Tg(KRT14-HPV16)wt1Dh/0
Genetic
Background		 either: FVB.Cg-Tg(KRT14-HPV16)wt1Dh or (involves: C57BL/6 * DBA/2 * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-HPV16)wt1Dh mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin squamous cell carcinoma incidence ( J:20130 )
• by 8 to 12 months, 21% of mice develop well differentiated and moderate to poorly differentiated squamous cell carcinomas
• malignant progression is accompanied by cell junction and extracellular matrix remodeling but is not defined by increased cell proliferation
increased spindle cell carcinoma incidence ( J:20130 )
• in 6 of 169 mice over the last 2 years

integument
abnormal skin morphology ( J:20130 )
• mice exhibit skin dysplasia compared with wild-type mice
increased skin squamous cell carcinoma incidence ( J:20130 )
• by 8 to 12 months, 21% of mice develop well differentiated and moderate to poorly differentiated squamous cell carcinomas
• malignant progression is accompanied by cell junction and extracellular matrix remodeling but is not defined by increased cell proliferation

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
skin squamous cell carcinoma DOID:3151 J:20130




Genotype
MGI:4849990
tg4
Allelic
Composition		 Tg(KRT14-HPV16)wt1Dh/0
Genetic
Background		 either: (involves: C57BL/6 * DBA/2) or (involves: C57BL/6 * DBA/2 * SENCAR * SSIN)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-HPV16)wt1Dh mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:20130 )
N
• Background Sensitivity: mice do not exhibit malignant carcinoma unlike mice on a background containing FVB/N

integument

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT skin squamous cell carcinoma DOID:3151 J:20130




Genotype
MGI:4367275
tg5
Allelic
Composition		 Tg(KRT14-HPV16)wt1Dh/0
Genetic
Background		 FVB.Cg-Tg(KRT14-HPV16)wt1Dh/Nci
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-HPV16)wt1Dh mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin squamous cell carcinoma incidence ( J:65699 )
• in 50% of mice by 12 months of age

integument
increased skin squamous cell carcinoma incidence ( J:65699 )
• in 50% of mice by 12 months of age

cellular




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory